ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cubilin

Intermolecular
Cysteine 81 and cysteine 81
Intramolecular
Cysteine 932 and cysteine 958
Cysteine 1218 and cysteine 1240
Cysteine 1333 and cysteine 1351
Cysteine 985 and cysteine 1005
Cysteine 1165 and cysteine 1191
Cysteine 1278 and cysteine 1306
Cysteine 1048 and cysteine 1074
A redox-regulated disulphide may form between two units of Cubilin at cysteines 81 and 81. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6gje
Structure name
structure of the amnionless(20-357)-cubilin(36-135) complex
Structure deposition date
2018-05-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
58
Peptide A name
Cubilin
Peptide B name
Cubilin
Peptide A accession
O60494
Peptide B accession
O60494
Peptide A residue number
81
Peptide B residue number
81

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cubilin between cysteines 932 and 958.

Details

Redox score ?
89
PDB code
3kq4
Structure name
structure of intrinsic factor-cobalamin bound to its receptor cubilin
Structure deposition date
2009-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60494
Residue number A
932
Residue number B
958
Peptide name
Cubilin

Ligandability

Cysteine 932 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 958 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cubilin between cysteines 1218 and 1240.

Details

Redox score ?
88
PDB code
3kq4
Structure name
structure of intrinsic factor-cobalamin bound to its receptor cubilin
Structure deposition date
2009-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60494
Residue number A
1218
Residue number B
1240
Peptide name
Cubilin

Ligandability

Cysteine 1218 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1240 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cubilin between cysteines 1333 and 1351.

Details

Redox score ?
88
PDB code
3kq4
Structure name
structure of intrinsic factor-cobalamin bound to its receptor cubilin
Structure deposition date
2009-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60494
Residue number A
1333
Residue number B
1351
Peptide name
Cubilin

Ligandability

Cysteine 1333 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1351 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cubilin between cysteines 985 and 1005.

Details

Redox score ?
86
PDB code
3kq4
Structure name
structure of intrinsic factor-cobalamin bound to its receptor cubilin
Structure deposition date
2009-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60494
Residue number A
985
Residue number B
1005
Peptide name
Cubilin

Ligandability

Cysteine 985 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1005 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cubilin between cysteines 1165 and 1191.

Details

Redox score ?
84
PDB code
3kq4
Structure name
structure of intrinsic factor-cobalamin bound to its receptor cubilin
Structure deposition date
2009-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60494
Residue number A
1165
Residue number B
1191
Peptide name
Cubilin

Ligandability

Cysteine 1165 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1191 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cubilin between cysteines 1278 and 1306.

Details

Redox score ?
84
PDB code
3kq4
Structure name
structure of intrinsic factor-cobalamin bound to its receptor cubilin
Structure deposition date
2009-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60494
Residue number A
1278
Residue number B
1306
Peptide name
Cubilin

Ligandability

Cysteine 1278 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1306 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cubilin between cysteines 1048 and 1074.

Details

Redox score ?
84
PDB code
3kq4
Structure name
structure of intrinsic factor-cobalamin bound to its receptor cubilin
Structure deposition date
2009-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60494
Residue number A
1048
Residue number B
1074
Peptide name
Cubilin

Ligandability

Cysteine 1048 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1074 of Cubilin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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