ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Docking protein 2

Intramolecular
Cysteine 164 and cysteine 217
Cysteine 65 and cysteine 110
A redox-regulated disulphide may form within Docking protein 2 between cysteines 164 and 217 (24 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
2dlw
Structure name
solution structure of the irs domain of human docking protein 2, isoform a
Structure deposition date
2006-04-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
22
Peptide accession
Q8N5A4
Residue number A
164
Residue number B
217
Peptide name
Docking protein 2

Ligandability

Cysteine 164 of Docking protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Docking protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Docking protein 2 between cysteines 65 and 110 (72 and 117 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2d9w
Structure name
solution structure of the ph domain of docking protein 2 from human
Structure deposition date
2005-12-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
29
Peptide accession
O60496
Residue number A
65
Residue number B
110
Peptide name
Docking protein 2

Ligandability

Cysteine 65 of Docking protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Docking protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: