ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein O-GlcNAcase

Intramolecular
Cysteine 220 and cysteine 224
Cysteine 215 and cysteine 220
A redox-regulated disulphide may form within Protein O-GlcNAcase between cysteines 220 and 224. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
6hki
Structure name
crystal structure of surface entropy mutant of human o-glcnac hydrolase
Structure deposition date
2018-09-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
74
Peptide accession
O60502
Residue number A
220
Residue number B
224
Peptide name
Protein O-GlcNAcase

Ligandability

Cysteine 220 of Protein O-GlcNAcase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 224 of Protein O-GlcNAcase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein O-GlcNAcase between cysteines 215 and 220. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
5un9
Structure name
the crystal structure of human o-glcnacase in complex with thiamet-g
Structure deposition date
2017-01-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
86
Peptide accession
O60502
Residue number A
215
Residue number B
220
Peptide name
Protein O-GlcNAcase

Ligandability

Cysteine 215 of Protein O-GlcNAcase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of Protein O-GlcNAcase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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