ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein-tyrosine sulfotransferase 1

Intramolecular
Cysteine 226 and cysteine 234
Cysteine 97 and cysteine 157
A redox-regulated disulphide may form within Protein-tyrosine sulfotransferase 1 between cysteines 226 and 234.

Details

Redox score ?
86
PDB code
5wrj
Structure name
crystal structure of human tyrosylprotein sulfotransferase-1 complexed with pap and gastrin peptide
Structure deposition date
2016-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60507
Residue number A
226
Residue number B
234
Peptide name
Protein-tyrosine sulfotransferase 1

Ligandability

Cysteine 226 of Protein-tyrosine sulfotransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 234 of Protein-tyrosine sulfotransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein-tyrosine sulfotransferase 1 between cysteines 97 and 157.

Details

Redox score ?
78
PDB code
5wri
Structure name
crystal structure of human tyrosylprotein sulfotransferase-1 complexed with pap and c4 peptide
Structure deposition date
2016-12-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60507
Residue number A
97
Residue number B
157
Peptide name
Protein-tyrosine sulfotransferase 1

Ligandability

Cysteine 97 of Protein-tyrosine sulfotransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of Protein-tyrosine sulfotransferase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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