ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pre-mRNA-processing factor 17

Intramolecular
Cysteine 512 and cysteine 553
Cysteine 553 and cysteine 569
Cysteine 339 and cysteine 378
Cysteine 512 and cysteine 569
Cysteine 307 and cysteine 569
A redox-regulated disulphide may form within Pre-mRNA-processing factor 17 between cysteines 512 and 553. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6icz
Structure name
cryo-em structure of a human post-catalytic spliceosome (p complex) at 3
Structure deposition date
2018-09-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
93
Minimum pKa ?
13
% buried
99
Peptide accession
O60508
Residue number A
512
Residue number B
553
Peptide name
Pre-mRNA-processing factor 17

Ligandability

Cysteine 512 of Pre-mRNA-processing factor 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 553 of Pre-mRNA-processing factor 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-processing factor 17 between cysteines 553 and 569. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7w5a
Structure name
the cryo-em structure of human pre-c*-ii complex
Structure deposition date
2021-11-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
91
Minimum pKa ?
11
% buried
98
Peptide accession
O60508
Residue number A
553
Residue number B
569
Peptide name
Pre-mRNA-processing factor 17

Ligandability

Cysteine 553 of Pre-mRNA-processing factor 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 569 of Pre-mRNA-processing factor 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-processing factor 17 between cysteines 339 and 378. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7w59
Structure name
the cryo-em structure of human pre-c*-i complex
Structure deposition date
2021-11-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
100
Peptide accession
O60508
Residue number A
339
Residue number B
378
Peptide name
Pre-mRNA-processing factor 17

Ligandability

Cysteine 339 of Pre-mRNA-processing factor 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 378 of Pre-mRNA-processing factor 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-processing factor 17 between cysteines 512 and 569. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7w59
Structure name
the cryo-em structure of human pre-c*-i complex
Structure deposition date
2021-11-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
98
Minimum pKa ?
11
% buried
100
Peptide accession
O60508
Residue number A
512
Residue number B
569
Peptide name
Pre-mRNA-processing factor 17

Ligandability

Cysteine 512 of Pre-mRNA-processing factor 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 569 of Pre-mRNA-processing factor 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-processing factor 17 between cysteines 307 and 569. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6icz
Structure name
cryo-em structure of a human post-catalytic spliceosome (p complex) at 3
Structure deposition date
2018-09-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
94
Minimum pKa ?
12
% buried
100
Peptide accession
O60508
Residue number A
307
Residue number B
569
Peptide name
Pre-mRNA-processing factor 17

Ligandability

Cysteine 307 of Pre-mRNA-processing factor 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 569 of Pre-mRNA-processing factor 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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