ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GDP-mannose 4,6 dehydratase

Intermolecular
Cysteine 142 and cysteine 142
A redox-regulated disulphide may form between two units of GDP-mannose 4,6 dehydratase at cysteines 142 and 142. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6gpj
Structure name
crystal structure of human gdp-d-mannose 4,6-dehydratase in complex with gdp-4f-man
Structure deposition date
2018-06-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
11
% buried
72
Peptide A name
GDP-mannose 4,6 dehydratase
Peptide B name
GDP-mannose 4,6 dehydratase
Peptide A accession
O60547
Peptide B accession
O60547
Peptide A residue number
142
Peptide B residue number
142

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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