Toll-like receptor 5
Intermolecular
Cysteine 646 and cysteine 646
Intramolecular
Cysteine 585 and cysteine 629
Cysteine 583 and cysteine 610
Cysteine 698 and cysteine 756
Cysteine 463 and cysteine 494
3j0a A 646 B 646
A redox-regulated disulphide may form between two units of Toll-like receptor 5 at cysteines 646 and 646. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3j0a
Structure name
homology model of human toll-like receptor 5 fitted into an electron microscopy single particle reconstruction
Structure deposition date
2011-06-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
0
Peptide A name
Toll-like receptor 5
Peptide B name
Toll-like receptor 5
Peptide A accession
O60602
Peptide B accession
O60602
Peptide A residue number
646
Peptide B residue number
646
Ligandability
3j0a A 585 A 629
A redox-regulated disulphide may form within Toll-like receptor 5 between cysteines 585 and 629.
Details
Redox score ?
90
PDB code
3j0a
Structure name
homology model of human toll-like receptor 5 fitted into an electron microscopy single particle reconstruction
Structure deposition date
2011-06-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60602
Residue number A
585
Residue number B
629
Peptide name
Toll-like receptor 5
Ligandability
Cysteine 585 of Toll-like receptor 5
Cysteine 629 of Toll-like receptor 5
3j0a A 583 A 610
A redox-regulated disulphide may form within Toll-like receptor 5 between cysteines 583 and 610.
Details
Redox score ?
84
PDB code
3j0a
Structure name
homology model of human toll-like receptor 5 fitted into an electron microscopy single particle reconstruction
Structure deposition date
2011-06-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60602
Residue number A
583
Residue number B
610
Peptide name
Toll-like receptor 5
Ligandability
Cysteine 583 of Toll-like receptor 5
Cysteine 610 of Toll-like receptor 5
3j0a A 698 A 756
A redox-regulated disulphide may form within Toll-like receptor 5 between cysteines 698 and 756. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
3j0a
Structure name
homology model of human toll-like receptor 5 fitted into an electron microscopy single particle reconstruction
Structure deposition date
2011-06-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
100
Peptide accession
O60602
Residue number A
698
Residue number B
756
Peptide name
Toll-like receptor 5
Ligandability
Cysteine 698 of Toll-like receptor 5
Cysteine 756 of Toll-like receptor 5
3j0a B 463 B 494
A redox-regulated disulphide may form within Toll-like receptor 5 between cysteines 463 and 494. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
3j0a
Structure name
homology model of human toll-like receptor 5 fitted into an electron microscopy single particle reconstruction
Structure deposition date
2011-06-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
81
Peptide accession
O60602
Residue number A
463
Residue number B
494
Peptide name
Toll-like receptor 5
Ligandability
Cysteine 463 of Toll-like receptor 5
Cysteine 494 of Toll-like receptor 5
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