ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GDNF family receptor alpha-3

Intramolecular
Cysteine 191 and cysteine 239
Cysteine 318 and cysteine 328
Cysteine 255 and cysteine 261
Cysteine 281 and cysteine 340
Cysteine 169 and cysteine 175
Cysteine 248 and cysteine 316
Cysteine 272 and cysteine 288
Cysteine 186 and cysteine 196
Cysteine 162 and cysteine 218
Cysteine 162 and cysteine 220
More...
Cysteine 196 and cysteine 239
Cysteine 162 and cysteine 227
Cysteine 288 and cysteine 340
Cysteine 248 and cysteine 318
Cysteine 281 and cysteine 288
Cysteine 248 and cysteine 328
Cysteine 191 and cysteine 196
Cysteine 186 and cysteine 239
Cysteine 272 and cysteine 340
Cysteine 218 and cysteine 220
Cysteine 220 and cysteine 227
Cysteine 186 and cysteine 191
Cysteine 316 and cysteine 318
Cysteine 272 and cysteine 281
Cysteine 218 and cysteine 227
Cysteine 316 and cysteine 328
A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 191 and 239.

Details

Redox score ?
88
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
191
Residue number B
239
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 191 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 318 and 328.

Details

Redox score ?
87
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
318
Residue number B
328
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 318 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 255 and 261.

Details

Redox score ?
86
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
255
Residue number B
261
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 255 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 261 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 281 and 340.

Details

Redox score ?
85
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
281
Residue number B
340
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 281 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 340 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 169 and 175.

Details

Redox score ?
85
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
169
Residue number B
175
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 169 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 175 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 248 and 316.

Details

Redox score ?
83
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
248
Residue number B
316
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 248 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 272 and 288.

Details

Redox score ?
83
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
272
Residue number B
288
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 272 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 288 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 186 and 196.

Details

Redox score ?
82
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
186
Residue number B
196
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 186 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 162 and 218.

Details

Redox score ?
82
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
162
Residue number B
218
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 162 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 162 and 220.

Details

Redox score ?
78
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
162
Residue number B
220
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 162 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 196 and 239.

Details

Redox score ?
75
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
196
Residue number B
239
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 196 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 162 and 227.

Details

Redox score ?
74
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
162
Residue number B
227
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 162 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 227 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 288 and 340.

Details

Redox score ?
74
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
288
Residue number B
340
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 288 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 340 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 248 and 318.

Details

Redox score ?
73
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
248
Residue number B
318
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 248 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 318 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 281 and 288.

Details

Redox score ?
72
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
281
Residue number B
288
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 281 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 288 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 248 and 328.

Details

Redox score ?
71
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
248
Residue number B
328
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 248 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 191 and 196.

Details

Redox score ?
70
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
191
Residue number B
196
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 191 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 186 and 239.

Details

Redox score ?
66
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
186
Residue number B
239
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 186 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 272 and 340.

Details

Redox score ?
66
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
272
Residue number B
340
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 272 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 340 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 218 and 220.

Details

Redox score ?
66
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
218
Residue number B
220
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 218 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 220 and 227.

Details

Redox score ?
66
PDB code
6q2s
Structure name
cryo-em structure of ret/gfra3/artn extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
43
Peptide accession
O60609
Residue number A
220
Residue number B
227
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 220 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 227 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 186 and 191.

Details

Redox score ?
65
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
186
Residue number B
191
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 186 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 191 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 316 and 318.

Details

Redox score ?
63
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
316
Residue number B
318
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 316 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 318 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 272 and 281.

Details

Redox score ?
62
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
272
Residue number B
281
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 272 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 281 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 218 and 227.

Details

Redox score ?
60
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
218
Residue number B
227
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 218 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 227 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-3 between cysteines 316 and 328.

Details

Redox score ?
60
PDB code
2gh0
Structure name
growth factor/receptor complex
Structure deposition date
2006-03-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60609
Residue number A
316
Residue number B
328
Peptide name
GDNF family receptor alpha-3

Ligandability

Cysteine 316 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of GDNF family receptor alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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