ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Intramolecular
Cysteine 528 and cysteine 533
Cysteine 731 and cysteine 737
Cysteine 724 and cysteine 731
A redox-regulated disulphide may form within High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A between cysteines 528 and 533.

Details

Redox score ?
86
PDB code
7cwf
Structure name
crystal structure of pde8a catalytic domain in complex with 2c
Structure deposition date
2020-08-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60658
Residue number A
528
Residue number B
533
Peptide name
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Ligandability

Cysteine 528 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 533 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A between cysteines 731 and 737. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7vtw
Structure name
crystal structure of pde8a catalytic domain in complex with 17
Structure deposition date
2021-10-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
96
Peptide accession
O60658
Residue number A
731
Residue number B
737
Peptide name
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Ligandability

Cysteine 731 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 737 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A between cysteines 724 and 731. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7cwf
Structure name
crystal structure of pde8a catalytic domain in complex with 2c
Structure deposition date
2020-08-28
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
13
% buried
100
Peptide accession
O60658
Residue number A
724
Residue number B
731
Peptide name
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Ligandability

Cysteine 724 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 731 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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