ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Monocarboxylate transporter 2

Intramolecular
Cysteine 96 and cysteine 97
Cysteine 96 and cysteine 189
Cysteine 327 and cysteine 331
Cysteine 97 and cysteine 189
Cysteine 331 and cysteine 410
A redox-regulated disulphide may form within Monocarboxylate transporter 2 between cysteines 96 and 97. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7bp3
Structure name
cryo-em structure of the human mct2
Structure deposition date
2020-03-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
55
Peptide accession
O60669
Residue number A
96
Residue number B
97
Peptide name
Monocarboxylate transporter 2

Ligandability

Cysteine 96 of Monocarboxylate transporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of Monocarboxylate transporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monocarboxylate transporter 2 between cysteines 96 and 189. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7bp3
Structure name
cryo-em structure of the human mct2
Structure deposition date
2020-03-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
11
% buried
68
Peptide accession
O60669
Residue number A
96
Residue number B
189
Peptide name
Monocarboxylate transporter 2

Ligandability

Cysteine 96 of Monocarboxylate transporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Monocarboxylate transporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monocarboxylate transporter 2 between cysteines 327 and 331. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7bp3
Structure name
cryo-em structure of the human mct2
Structure deposition date
2020-03-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
72
Peptide accession
O60669
Residue number A
327
Residue number B
331
Peptide name
Monocarboxylate transporter 2

Ligandability

Cysteine 327 of Monocarboxylate transporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 331 of Monocarboxylate transporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monocarboxylate transporter 2 between cysteines 97 and 189. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7bp3
Structure name
cryo-em structure of the human mct2
Structure deposition date
2020-03-21
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
10
% buried
40
Peptide accession
O60669
Residue number A
97
Residue number B
189
Peptide name
Monocarboxylate transporter 2

Ligandability

Cysteine 97 of Monocarboxylate transporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Monocarboxylate transporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Monocarboxylate transporter 2 between cysteines 331 and 410. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7bp3
Structure name
cryo-em structure of the human mct2
Structure deposition date
2020-03-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
84
Peptide accession
O60669
Residue number A
331
Residue number B
410
Peptide name
Monocarboxylate transporter 2

Ligandability

Cysteine 331 of Monocarboxylate transporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 410 of Monocarboxylate transporter 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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