DNA polymerase zeta catalytic subunit
Intermolecular
Cysteine 144 of Mitotic spindle assembly checkpoint protein MAD2B and cysteine 1999
Cysteine 70 of Mitotic spindle assembly checkpoint protein MAD2B and cysteine 1997
Cysteine 1999 and cysteine 1999
Intramolecular
Cysteine 1997 and cysteine 1999
6bi7 E 144 F 1999
A redox-regulated disulphide may form between cysteine 144 of Mitotic spindle assembly checkpoint protein MAD2B and cysteine 1999 of DNA polymerase zeta catalytic subunit. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6bi7
Structure name
crystal structure of rev7-wt/rev3 as a monomer under high-salt conditions
Structure deposition date
2017-11-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
27
Peptide A name
Mitotic spindle assembly checkpoint protein MAD2B
Peptide B name
DNA polymerase zeta catalytic subunit
Peptide A accession
Q9UI95
Peptide B accession
O60673
Peptide A residue number
144
Peptide B residue number
1999
Ligandability
Cysteine 144 of Mitotic spindle assembly checkpoint protein MAD2B
Cysteine 1999 of DNA polymerase zeta catalytic subunit
6ekm A 70 B 1997
A redox-regulated disulphide may form between cysteine 70 of Mitotic spindle assembly checkpoint protein MAD2B and cysteine 1997 of DNA polymerase zeta catalytic subunit. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
6ekm
Structure name
crystal structure of mammalian rev7 in complex with human rev3 second binding site
Structure deposition date
2017-09-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
34
Peptide A name
Mitotic spindle assembly checkpoint protein MAD2B
Peptide B name
DNA polymerase zeta catalytic subunit
Peptide A accession
Q9D752
Peptide B accession
O60673
Peptide A residue number
70
Peptide B residue number
1997
Ligandability
Cysteine 70 of Mitotic spindle assembly checkpoint protein MAD2B
Cysteine 1997 of DNA polymerase zeta catalytic subunit
6bi7 D 1999 H 1999
A redox-regulated disulphide may form between two units of DNA polymerase zeta catalytic subunit at cysteines 1999 and 1999. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
6bi7
Structure name
crystal structure of rev7-wt/rev3 as a monomer under high-salt conditions
Structure deposition date
2017-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
78
Peptide A name
DNA polymerase zeta catalytic subunit
Peptide B name
DNA polymerase zeta catalytic subunit
Peptide A accession
O60673
Peptide B accession
O60673
Peptide A residue number
1999
Peptide B residue number
1999
Ligandability
6bi7 H 1997 H 1999
A redox-regulated disulphide may form within DNA polymerase zeta catalytic subunit between cysteines 1997 and 1999. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6bi7
Structure name
crystal structure of rev7-wt/rev3 as a monomer under high-salt conditions
Structure deposition date
2017-11-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
60
Peptide accession
O60673
Residue number A
1997
Residue number B
1999
Peptide name
DNA polymerase zeta catalytic subunit
Ligandability
Cysteine 1997 of DNA polymerase zeta catalytic subunit
Cysteine 1999 of DNA polymerase zeta catalytic subunit
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