Tyrosine-protein kinase JAK2
Intermolecular
Cysteine 125 and cysteine 314 of Erythropoietin receptor L
Intramolecular
Cysteine 616 and cysteine 618
Cysteine 400 and cysteine 427
Cysteine 498 and cysteine 499
Cysteine 178 and cysteine 213
Cysteine 866 and cysteine 917
Cysteine 400 and cysteine 498
Cysteine 961 and cysteine 1105
6e2q B 125 O 314
A redox-regulated disulphide may form between cysteine 125 of Tyrosine-protein kinase JAK2 and cysteine 314 of Erythropoietin receptor. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6e2q
Structure name
structure of human jak2 ferm/sh2 in complex with erythropoietin receptor
Structure deposition date
2018-07-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
86
Peptide A name
Tyrosine-protein kinase JAK2
Peptide B name
Erythropoietin receptor
Peptide A accession
O60674
Peptide B accession
P19235
Peptide A residue number
125
Peptide B residue number
314
Ligandability
Cysteine 125 of Tyrosine-protein kinase JAK2
Cysteine 314 of Erythropoietin receptor
5wim A 616 A 618
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK2 between cysteines 616 and 618.
Details
Redox score ?
80
PDB code
5wim
Structure name
jak2 pseudokinase in complex with at9283
Structure deposition date
2017-07-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
32
Peptide accession
O60674
Residue number A
616
Residue number B
618
Peptide name
Tyrosine-protein kinase JAK2
Ligandability
Cysteine 616 of Tyrosine-protein kinase JAK2
Cysteine 618 of Tyrosine-protein kinase JAK2
6e2p A 400 A 427
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK2 between cysteines 400 and 427.
Details
Redox score ?
70
PDB code
6e2p
Structure name
structure of human jak2 ferm/sh2 in complex with leptin receptor
Structure deposition date
2018-07-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
100
Peptide accession
O60674
Residue number A
400
Residue number B
427
Peptide name
Tyrosine-protein kinase JAK2
Ligandability
Cysteine 400 of Tyrosine-protein kinase JAK2
Cysteine 427 of Tyrosine-protein kinase JAK2
6e2q C 498 C 499
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK2 between cysteines 498 and 499. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
6e2q
Structure name
structure of human jak2 ferm/sh2 in complex with erythropoietin receptor
Structure deposition date
2018-07-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
48
Peptide accession
O60674
Residue number A
498
Residue number B
499
Peptide name
Tyrosine-protein kinase JAK2
Ligandability
Cysteine 498 of Tyrosine-protein kinase JAK2
Cysteine 499 of Tyrosine-protein kinase JAK2
6e2q B 178 B 213
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK2 between cysteines 178 and 213. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
6e2q
Structure name
structure of human jak2 ferm/sh2 in complex with erythropoietin receptor
Structure deposition date
2018-07-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
73
Peptide accession
O60674
Residue number A
178
Residue number B
213
Peptide name
Tyrosine-protein kinase JAK2
Ligandability
Cysteine 178 of Tyrosine-protein kinase JAK2
Cysteine 213 of Tyrosine-protein kinase JAK2
4gfm A 866 A 917
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK2 between cysteines 866 and 917. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
4gfm
Structure name
jak2 kinase (jh1 domain) with 2,6-dichloro-n-(2-oxo-2,5- dihydropyridin-4-yl)benzamide
Structure deposition date
2012-08-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
54
Peptide accession
O60674
Residue number A
866
Residue number B
917
Peptide name
Tyrosine-protein kinase JAK2
Ligandability
Cysteine 866 of Tyrosine-protein kinase JAK2
Cysteine 917 of Tyrosine-protein kinase JAK2
6e2q A 400 A 498
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK2 between cysteines 400 and 498. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6e2q
Structure name
structure of human jak2 ferm/sh2 in complex with erythropoietin receptor
Structure deposition date
2018-07-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
88
Peptide accession
O60674
Residue number A
400
Residue number B
498
Peptide name
Tyrosine-protein kinase JAK2
Ligandability
Cysteine 400 of Tyrosine-protein kinase JAK2
Cysteine 498 of Tyrosine-protein kinase JAK2
5tq4 A 961 A 1105
A redox-regulated disulphide may form within Tyrosine-protein kinase JAK2 between cysteines 961 and 1105. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
5tq4
Structure name
design and synthesis of a pan-jak kinase inhibitor clinical candidate (pf-06263276) suitable for inhaled and topical delivery for the treatment of inflammatory diseases of the lungs and skin
Structure deposition date
2016-10-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
86
Peptide accession
O60674
Residue number A
961
Residue number B
1105
Peptide name
Tyrosine-protein kinase JAK2
Ligandability
Cysteine 961 of Tyrosine-protein kinase JAK2
Cysteine 1105 of Tyrosine-protein kinase JAK2
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