ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Importin subunit alpha-7

Intramolecular
Cysteine 238 and cysteine 253
Cysteine 296 and cysteine 335
Cysteine 335 and cysteine 340
Cysteine 422 and cysteine 427
A redox-regulated disulphide may form within Importin subunit alpha-7 between cysteines 238 and 253.

Details

Redox score ?
67
PDB code
4uad
Structure name
importin alpha 7 delta ibb in complex with influenza pb2 nuclear localization domain
Structure deposition date
2014-08-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
9
% buried
98
Peptide accession
O60684
Residue number A
238
Residue number B
253
Peptide name
Importin subunit alpha-7

Ligandability

Cysteine 238 of Importin subunit alpha-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 253 of Importin subunit alpha-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Importin subunit alpha-7 between cysteines 296 and 335.

Details

Redox score ?
66
PDB code
7rht
Structure name
importin alpha 7 delta ibb (kpna6)
Structure deposition date
2021-07-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
54
Peptide accession
O60684
Residue number A
296
Residue number B
335
Peptide name
Importin subunit alpha-7

Ligandability

Cysteine 296 of Importin subunit alpha-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of Importin subunit alpha-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Importin subunit alpha-7 between cysteines 335 and 340. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
4uad
Structure name
importin alpha 7 delta ibb in complex with influenza pb2 nuclear localization domain
Structure deposition date
2014-08-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
38
Peptide accession
O60684
Residue number A
335
Residue number B
340
Peptide name
Importin subunit alpha-7

Ligandability

Cysteine 335 of Importin subunit alpha-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 340 of Importin subunit alpha-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Importin subunit alpha-7 between cysteines 422 and 427. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
4uad
Structure name
importin alpha 7 delta ibb in complex with influenza pb2 nuclear localization domain
Structure deposition date
2014-08-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
89
Peptide accession
O60684
Residue number A
422
Residue number B
427
Peptide name
Importin subunit alpha-7

Ligandability

Cysteine 422 of Importin subunit alpha-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 427 of Importin subunit alpha-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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