ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein-tyrosine sulfotransferase 2

Intramolecular
Cysteine 225 and cysteine 233
Cysteine 96 and cysteine 156
A redox-regulated disulphide may form within Protein-tyrosine sulfotransferase 2 between cysteines 225 and 233.

Details

Redox score ?
85
PDB code
3ap3
Structure name
crystal structure of human tyrosylprotein sulfotransferase-2 complexed with pap
Structure deposition date
2010-10-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60704
Residue number A
225
Residue number B
233
Peptide name
Protein-tyrosine sulfotransferase 2

Ligandability

Cysteine 225 of Protein-tyrosine sulfotransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 233 of Protein-tyrosine sulfotransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein-tyrosine sulfotransferase 2 between cysteines 96 and 156.

Details

Redox score ?
77
PDB code
3ap3
Structure name
crystal structure of human tyrosylprotein sulfotransferase-2 complexed with pap
Structure deposition date
2010-10-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60704
Residue number A
96
Residue number B
156
Peptide name
Protein-tyrosine sulfotransferase 2

Ligandability

Cysteine 96 of Protein-tyrosine sulfotransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 156 of Protein-tyrosine sulfotransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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