ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ATP-binding cassette sub-family C member 9

Intramolecular
Cysteine 6 and cysteine 24
Cysteine 1407 and cysteine 1409
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 9 between cysteines 6 and 24.

Details

Redox score ?
82
PDB code
7mit
Structure name
vascular katp channel: kir6
Structure deposition date
2021-04-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q63563
Residue number A
6
Residue number B
24
Peptide name
ATP-binding cassette sub-family C member 9

Ligandability

Cysteine 6 of ATP-binding cassette sub-family C member 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 24 of ATP-binding cassette sub-family C member 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 9 between cysteines 1407 and 1409. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7vlu
Structure name
structure of sur2a in complex with mg-atp/adp and p1075
Structure deposition date
2021-10-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
40
Minimum pKa ?
10
% buried
20
Peptide accession
Q63563
Residue number A
1407
Residue number B
1409
Peptide name
ATP-binding cassette sub-family C member 9

Ligandability

Cysteine 1407 of ATP-binding cassette sub-family C member 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1409 of ATP-binding cassette sub-family C member 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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