ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Leupaxin

Intramolecular
Cysteine 296 and cysteine 299
Cysteine 296 and cysteine 317
Cysteine 299 and cysteine 317
Cysteine 270 and cysteine 273
Cysteine 270 and cysteine 293
Cysteine 273 and cysteine 293
A redox-regulated disulphide may form within Leupaxin between cysteines 296 and 299 (44 and 47 respectively in this structure).

Details

Redox score ?
92
PDB code
1x3h
Structure name
solution structure of the lim domain of human leupaxin
Structure deposition date
2005-05-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
42
Minimum pKa ?
5
% buried
4
Peptide accession
O60711
Residue number A
296
Residue number B
299
Peptide name
Leupaxin

Ligandability

Cysteine 296 of Leupaxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of Leupaxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leupaxin between cysteines 296 and 317 (44 and 65 respectively in this structure).

Details

Redox score ?
88
PDB code
1x3h
Structure name
solution structure of the lim domain of human leupaxin
Structure deposition date
2005-05-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
5
% buried
4
Peptide accession
O60711
Residue number A
296
Residue number B
317
Peptide name
Leupaxin

Ligandability

Cysteine 296 of Leupaxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Leupaxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leupaxin between cysteines 299 and 317 (47 and 65 respectively in this structure).

Details

Redox score ?
83
PDB code
1x3h
Structure name
solution structure of the lim domain of human leupaxin
Structure deposition date
2005-05-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
0
Peptide accession
O60711
Residue number A
299
Residue number B
317
Peptide name
Leupaxin

Ligandability

Cysteine 299 of Leupaxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Leupaxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leupaxin between cysteines 270 and 273 (18 and 21 respectively in this structure).

Details

Redox score ?
83
PDB code
1x3h
Structure name
solution structure of the lim domain of human leupaxin
Structure deposition date
2005-05-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
7
% buried
2
Peptide accession
O60711
Residue number A
270
Residue number B
273
Peptide name
Leupaxin

Ligandability

Cysteine 270 of Leupaxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 273 of Leupaxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leupaxin between cysteines 270 and 293 (18 and 41 respectively in this structure).

Details

Redox score ?
82
PDB code
1x3h
Structure name
solution structure of the lim domain of human leupaxin
Structure deposition date
2005-05-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
7
% buried
2
Peptide accession
O60711
Residue number A
270
Residue number B
293
Peptide name
Leupaxin

Ligandability

Cysteine 270 of Leupaxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 293 of Leupaxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leupaxin between cysteines 273 and 293 (21 and 41 respectively in this structure).

Details

Redox score ?
81
PDB code
1x3h
Structure name
solution structure of the lim domain of human leupaxin
Structure deposition date
2005-05-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
0
Peptide accession
O60711
Residue number A
273
Residue number B
293
Peptide name
Leupaxin

Ligandability

Cysteine 273 of Leupaxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 293 of Leupaxin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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