ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Hematopoietic prostaglandin D synthase

Intermolecular
Cysteine 101 and cysteine 101
A redox-regulated disulphide may form between two units of Hematopoietic prostaglandin D synthase at cysteines 101 and 101. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5aiv
Structure name
complex of human hematopoietic prostagandin d2 synthase (hh- pgds) in complex with an active site inhibitor
Structure deposition date
2015-02-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
10
% buried
95
Peptide A name
Hematopoietic prostaglandin D synthase
Peptide B name
Hematopoietic prostaglandin D synthase
Peptide A accession
O60760
Peptide B accession
O60760
Peptide A residue number
101
Peptide B residue number
101

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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