ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

General vesicular transport factor p115

Intramolecular
Cysteine 383 and cysteine 439 L
Cysteine 388 and cysteine 391 L
Cysteine 317 and cysteine 388
Cysteine 426 and cysteine 478
Cysteine 499 and cysteine 541
A redox-regulated disulphide may form within General vesicular transport factor p115 between cysteines 383 and 439. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3gq2
Structure name
crystal structure of the dimer of the p115 tether globular head domain
Structure deposition date
2009-03-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
91
Peptide accession
P41541
Residue number A
383
Residue number B
439
Peptide name
General vesicular transport factor p115

Ligandability

Cysteine 383 of General vesicular transport factor p115

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 439 of General vesicular transport factor p115

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General vesicular transport factor p115 between cysteines 388 and 391. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2w3c
Structure name
globular head region of the human general vesicular transport factor p115
Structure deposition date
2008-11-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
O60763
Residue number A
388
Residue number B
391
Peptide name
General vesicular transport factor p115

Ligandability

Cysteine 388 of General vesicular transport factor p115

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 391 of General vesicular transport factor p115

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General vesicular transport factor p115 between cysteines 317 and 388. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2w3c
Structure name
globular head region of the human general vesicular transport factor p115
Structure deposition date
2008-11-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
96
Peptide accession
O60763
Residue number A
317
Residue number B
388
Peptide name
General vesicular transport factor p115

Ligandability

Cysteine 317 of General vesicular transport factor p115

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 388 of General vesicular transport factor p115

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General vesicular transport factor p115 between cysteines 426 and 478. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2w3c
Structure name
globular head region of the human general vesicular transport factor p115
Structure deposition date
2008-11-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
85
Peptide accession
O60763
Residue number A
426
Residue number B
478
Peptide name
General vesicular transport factor p115

Ligandability

Cysteine 426 of General vesicular transport factor p115

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 478 of General vesicular transport factor p115

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within General vesicular transport factor p115 between cysteines 499 and 541. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
2w3c
Structure name
globular head region of the human general vesicular transport factor p115
Structure deposition date
2008-11-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide accession
O60763
Residue number A
499
Residue number B
541
Peptide name
General vesicular transport factor p115

Ligandability

Cysteine 499 of General vesicular transport factor p115

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 541 of General vesicular transport factor p115

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: