ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Eukaryotic translation initiation factor 5B

Intramolecular
Cysteine 635 and cysteine 720
Cysteine 720 and cysteine 749
Cysteine 635 and cysteine 749
A redox-regulated disulphide may form within Eukaryotic translation initiation factor 5B between cysteines 635 and 720.

Details

Redox score ?
77
PDB code
7tql
Structure name
cryoem structure of the human 40s small ribosomal subunit in complex with translation initiation factors eif1a and eif5b
Structure deposition date
2022-01-26
Thiol separation (Å)
3
Half-sphere exposure sum ?
71
Minimum pKa ?
7
% buried
90
Peptide accession
O60841
Residue number A
635
Residue number B
720
Peptide name
Eukaryotic translation initiation factor 5B

Ligandability

Cysteine 635 of Eukaryotic translation initiation factor 5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 720 of Eukaryotic translation initiation factor 5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 5B between cysteines 720 and 749. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
7tql
Structure name
cryoem structure of the human 40s small ribosomal subunit in complex with translation initiation factors eif1a and eif5b
Structure deposition date
2022-01-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
54
Peptide accession
O60841
Residue number A
720
Residue number B
749
Peptide name
Eukaryotic translation initiation factor 5B

Ligandability

Cysteine 720 of Eukaryotic translation initiation factor 5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 749 of Eukaryotic translation initiation factor 5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Eukaryotic translation initiation factor 5B between cysteines 635 and 749. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7tql
Structure name
cryoem structure of the human 40s small ribosomal subunit in complex with translation initiation factors eif1a and eif5b
Structure deposition date
2022-01-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
7
% buried
64
Peptide accession
O60841
Residue number A
635
Residue number B
749
Peptide name
Eukaryotic translation initiation factor 5B

Ligandability

Cysteine 635 of Eukaryotic translation initiation factor 5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 749 of Eukaryotic translation initiation factor 5B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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