a tool for identifying drug-targetable redox-active disulphides

SH2 domain-containing protein 1A

Intramolecular

Cysteine 42 and cysteine 44

A redox-regulated disulphide may form within SH2 domain-containing protein 1A between cysteines 42 and 44 (4042 and 4044 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

58

PDB code

Structure name

crystal structure of the xlp protein sap

Structure deposition date

1999-09-22

Thiol separation (Å)

5

Half-sphere exposure sum ?

85

Minimum pK_a ?

8

% buried

100

Peptide accession

Residue number A

42

Residue number B

44

Peptide name

SH2 domain-containing protein 1A

Ligandability

Cysteine 42 of SH2 domain-containing protein 1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 44 of SH2 domain-containing protein 1A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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