ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Receptor activity-modifying protein 2

Intermolecular
Cysteine 99 and cysteine 99
Intramolecular
Cysteine 84 and cysteine 131
Cysteine 68 and cysteine 99
A redox-regulated disulphide may form between two units of Receptor activity-modifying protein 2 at cysteines 99 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3aqe
Structure name
crystal structure of the extracellular domain of human ramp2
Structure deposition date
2010-10-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide A name
Receptor activity-modifying protein 2
Peptide B name
Receptor activity-modifying protein 2
Peptide A accession
O60895
Peptide B accession
O60895
Peptide A residue number
99
Peptide B residue number
99

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor activity-modifying protein 2 between cysteines 84 and 131.

Details

Redox score ?
87
PDB code
3aqe
Structure name
crystal structure of the extracellular domain of human ramp2
Structure deposition date
2010-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60895
Residue number A
84
Residue number B
131
Peptide name
Receptor activity-modifying protein 2

Ligandability

Cysteine 84 of Receptor activity-modifying protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 131 of Receptor activity-modifying protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor activity-modifying protein 2 between cysteines 68 and 99.

Details

Redox score ?
82
PDB code
3aqe
Structure name
crystal structure of the extracellular domain of human ramp2
Structure deposition date
2010-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60895
Residue number A
68
Residue number B
99
Peptide name
Receptor activity-modifying protein 2

Ligandability

Cysteine 68 of Receptor activity-modifying protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of Receptor activity-modifying protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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