ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Receptor activity-modifying protein 3

Intramolecular
Cysteine 57 and cysteine 104
Cysteine 40 and cysteine 72
A redox-regulated disulphide may form within Receptor activity-modifying protein 3 between cysteines 57 and 104.

Details

Redox score ?
87
PDB code
6uva
Structure name
cryoem structure of the active adrenomedullin 2 receptor g protein complex with adrenomedullin 2 peptide
Structure deposition date
2019-11-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60896
Residue number A
57
Residue number B
104
Peptide name
Receptor activity-modifying protein 3

Ligandability

Cysteine 57 of Receptor activity-modifying protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Receptor activity-modifying protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor activity-modifying protein 3 between cysteines 40 and 72.

Details

Redox score ?
85
PDB code
6uva
Structure name
cryoem structure of the active adrenomedullin 2 receptor g protein complex with adrenomedullin 2 peptide
Structure deposition date
2019-11-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60896
Residue number A
40
Residue number B
72
Peptide name
Receptor activity-modifying protein 3

Ligandability

Cysteine 40 of Receptor activity-modifying protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of Receptor activity-modifying protein 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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