Sodium channel subunit beta-2
Intermolecular
Cysteine 55 and cysteine 911 of Sodium channel protein type 3 subunit alpha
Cysteine 55 and cysteine 910 of Sodium channel protein type 2 subunit alpha
Cysteine 895 of Sodium channel protein type 9 subunit alpha and cysteine 55
Cysteine 903 of Sodium channel protein type 9 subunit alpha and cysteine 55
Cysteine 55 and cysteine 912 of Sodium channel protein type 2 subunit alpha
Cysteine 897 of Sodium channel protein type 9 subunit alpha and cysteine 55
Intramolecular
Cysteine 72 and cysteine 75
Cysteine 50 and cysteine 127
7w7f C 55 D 911
A redox-regulated disulphide may form between cysteine 55 of Sodium channel subunit beta-2 and cysteine 911 of Sodium channel protein type 3 subunit alpha.
Details
Redox score ?
81
PDB code
7w7f
Structure name
cryo-em structure of human nav1
Structure deposition date
2021-12-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide A name
Sodium channel subunit beta-2
Peptide B name
Sodium channel protein type 3 subunit alpha
Peptide A accession
O60939
Peptide B accession
Q9NY46
Peptide A residue number
55
Peptide B residue number
911
Ligandability
Cysteine 55 of Sodium channel subunit beta-2
Cysteine 911 of Sodium channel protein type 3 subunit alpha
6j8e C 55 A 910
A redox-regulated disulphide may form between cysteine 55 of Sodium channel subunit beta-2 and cysteine 910 of Sodium channel protein type 2 subunit alpha.
Details
Redox score ?
78
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide A name
Sodium channel subunit beta-2
Peptide B name
Sodium channel protein type 2 subunit alpha
Peptide A accession
O60939
Peptide B accession
Q99250
Peptide A residue number
55
Peptide B residue number
910
Ligandability
Cysteine 55 of Sodium channel subunit beta-2
Cysteine 910 of Sodium channel protein type 2 subunit alpha
7xmf A 895 C 55
A redox-regulated disulphide may form between cysteine 895 of Sodium channel protein type 9 subunit alpha and cysteine 55 of Sodium channel subunit beta-2.
Details
Redox score ?
73
PDB code
7xmf
Structure name
cryo-em structure of human nav1
Structure deposition date
2022-04-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
42
Peptide A name
Sodium channel protein type 9 subunit alpha
Peptide B name
Sodium channel subunit beta-2
Peptide A accession
Q15858
Peptide B accession
O60939
Peptide A residue number
895
Peptide B residue number
55
Ligandability
Cysteine 895 of Sodium channel protein type 9 subunit alpha
Cysteine 55 of Sodium channel subunit beta-2
7xmg A 903 F 55
A redox-regulated disulphide may form between cysteine 903 of Sodium channel protein type 9 subunit alpha and cysteine 55 of Sodium channel subunit beta-2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7xmg
Structure name
cryo-em structure of human nav1
Structure deposition date
2022-04-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide A name
Sodium channel protein type 9 subunit alpha
Peptide B name
Sodium channel subunit beta-2
Peptide A accession
Q15858
Peptide B accession
O60939
Peptide A residue number
903
Peptide B residue number
55
Ligandability
Cysteine 903 of Sodium channel protein type 9 subunit alpha
Cysteine 55 of Sodium channel subunit beta-2
6j8e C 55 A 912
A redox-regulated disulphide may form between cysteine 55 of Sodium channel subunit beta-2 and cysteine 912 of Sodium channel protein type 2 subunit alpha. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6j8e
Structure name
human nav1
Structure deposition date
2019-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide A name
Sodium channel subunit beta-2
Peptide B name
Sodium channel protein type 2 subunit alpha
Peptide A accession
O60939
Peptide B accession
Q99250
Peptide A residue number
55
Peptide B residue number
912
Ligandability
Cysteine 55 of Sodium channel subunit beta-2
Cysteine 912 of Sodium channel protein type 2 subunit alpha
7w9l A 897 C 55
A redox-regulated disulphide may form between cysteine 897 of Sodium channel protein type 9 subunit alpha and cysteine 55 of Sodium channel subunit beta-2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7w9l
Structure name
cryo-em structure of human nav1
Structure deposition date
2021-12-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide A name
Sodium channel protein type 9 subunit alpha
Peptide B name
Sodium channel subunit beta-2
Peptide A accession
Q15858
Peptide B accession
O60939
Peptide A residue number
897
Peptide B residue number
55
Ligandability
Cysteine 897 of Sodium channel protein type 9 subunit alpha
Cysteine 55 of Sodium channel subunit beta-2
6vrr A 72 A 75
A redox-regulated disulphide may form within Sodium channel subunit beta-2 between cysteines 72 and 75.
Details
Redox score ?
87
PDB code
6vrr
Structure name
crystal structure of a disease mutant of the voltage-gated sodium channel beta 2 subunit extracellular domain
Structure deposition date
2020-02-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
29
Minimum pKa ?
nan
% buried
nan
Peptide accession
O60939
Residue number A
72
Residue number B
75
Peptide name
Sodium channel subunit beta-2
Ligandability
Cysteine 72 of Sodium channel subunit beta-2
Cysteine 75 of Sodium channel subunit beta-2
6vrr A 50 A 127
A redox-regulated disulphide may form within Sodium channel subunit beta-2 between cysteines 50 and 127.
Details
Redox score ?
72
PDB code
6vrr
Structure name
crystal structure of a disease mutant of the voltage-gated sodium channel beta 2 subunit extracellular domain
Structure deposition date
2020-02-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
60
Peptide accession
O60939
Residue number A
50
Residue number B
127
Peptide name
Sodium channel subunit beta-2
Ligandability
Cysteine 50 of Sodium channel subunit beta-2
Cysteine 127 of Sodium channel subunit beta-2
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