ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Chymase 2

Intramolecular
Cysteine 144 and cysteine 209
Cysteine 175 and cysteine 188
Cysteine 51 and cysteine 67
A redox-regulated disulphide may form within Chymase 2 between cysteines 144 and 209 (136 and 201 respectively in this structure).

Details

Redox score ?
84
PDB code
2rdl
Structure name
hamster chymase 2
Structure deposition date
2007-09-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O70164
Residue number A
144
Residue number B
209
Peptide name
Chymase 2

Ligandability

Cysteine 144 of Chymase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 209 of Chymase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chymase 2 between cysteines 175 and 188 (168 and 182 respectively in this structure).

Details

Redox score ?
81
PDB code
2rdl
Structure name
hamster chymase 2
Structure deposition date
2007-09-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
O70164
Residue number A
175
Residue number B
188
Peptide name
Chymase 2

Ligandability

Cysteine 175 of Chymase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of Chymase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chymase 2 between cysteines 51 and 67 (42 and 58 respectively in this structure).

Details

Redox score ?
78
PDB code
2rdl
Structure name
hamster chymase 2
Structure deposition date
2007-09-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide accession
O70164
Residue number A
51
Residue number B
67
Peptide name
Chymase 2

Ligandability

Cysteine 51 of Chymase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 67 of Chymase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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