ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Low affinity immunoglobulin gamma Fc region receptor III-B

Intramolecular
Cysteine 47 and cysteine 89
Cysteine 128 and cysteine 172
A redox-regulated disulphide may form within Low affinity immunoglobulin gamma Fc region receptor III-B between cysteines 47 and 89 (26 and 68 respectively in this structure).

Details

Redox score ?
84
PDB code
1e4j
Structure name
crystal structure of the soluble human fc-gamma receptor iii
Structure deposition date
2000-07-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75015
Residue number A
47
Residue number B
89
Peptide name
Low affinity immunoglobulin gamma Fc region receptor III-B

Ligandability

Cysteine 47 of Low affinity immunoglobulin gamma Fc region receptor III-B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 89 of Low affinity immunoglobulin gamma Fc region receptor III-B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Low affinity immunoglobulin gamma Fc region receptor III-B between cysteines 128 and 172 (110 and 154 respectively in this structure).

Details

Redox score ?
81
PDB code
1t83
Structure name
crystal structure of a human type iii fc gamma receptor in complex with an fc fragment of igg1 (orthorhombic)
Structure deposition date
2004-05-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75015
Residue number A
128
Residue number B
172
Peptide name
Low affinity immunoglobulin gamma Fc region receptor III-B

Ligandability

Cysteine 128 of Low affinity immunoglobulin gamma Fc region receptor III-B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of Low affinity immunoglobulin gamma Fc region receptor III-B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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