ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

SLIT-ROBO Rho GTPase-activating protein 2

Intramolecular
Cysteine 279 and cysteine 280
Cysteine 39 and cysteine 279
Cysteine 34 and cysteine 39 L
A redox-regulated disulphide may form within SLIT-ROBO Rho GTPase-activating protein 2 between cysteines 279 and 280.

Details

Redox score ?
80
PDB code
5i6j
Structure name
crystal structure of srgap2 f-barx
Structure deposition date
2016-02-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
21
Peptide accession
O75044
Residue number A
279
Residue number B
280
Peptide name
SLIT-ROBO Rho GTPase-activating protein 2

Ligandability

Cysteine 279 of SLIT-ROBO Rho GTPase-activating protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of SLIT-ROBO Rho GTPase-activating protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SLIT-ROBO Rho GTPase-activating protein 2 between cysteines 39 and 279. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5i7d
Structure name
crystal structure of srgap2 f-barx wt form-2
Structure deposition date
2016-02-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
34
Peptide accession
O75044
Residue number A
39
Residue number B
279
Peptide name
SLIT-ROBO Rho GTPase-activating protein 2

Ligandability

Cysteine 39 of SLIT-ROBO Rho GTPase-activating protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of SLIT-ROBO Rho GTPase-activating protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SLIT-ROBO Rho GTPase-activating protein 2 between cysteines 34 and 39. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
5i6r
Structure name
crystal structure of srgap2 f-barx wt form-1
Structure deposition date
2016-02-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
21
Peptide accession
O75044
Residue number A
34
Residue number B
39
Peptide name
SLIT-ROBO Rho GTPase-activating protein 2

Ligandability

Cysteine 34 of SLIT-ROBO Rho GTPase-activating protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 39 of SLIT-ROBO Rho GTPase-activating protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: