Frizzled-7
Intramolecular
Cysteine 210 and cysteine 230
Cysteine 94 and cysteine 131
Cysteine 49 and cysteine 110
Cysteine 336 and cysteine 411
Cysteine 120 and cysteine 160
Cysteine 57 and cysteine 103
Cysteine 234 and cysteine 315
Cysteine 124 and cysteine 148
Cysteine 264 and cysteine 265
7evw R 210 R 230
A redox-regulated disulphide may form within Frizzled-7 between cysteines 210 and 230.
Details
Redox score ?
88
PDB code
7evw
Structure name
fzd7 -gs complex
Structure deposition date
2021-05-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75084
Residue number A
210
Residue number B
230
Peptide name
Frizzled-7
Ligandability
Cysteine 210 of Frizzled-7
Cysteine 230 of Frizzled-7
6o3b H 94 H 131
A redox-regulated disulphide may form within Frizzled-7 between cysteines 94 and 131.
Details
Redox score ?
85
PDB code
6o3b
Structure name
crystal structure of frizzled 7 crd in complex with f6 fab
Structure deposition date
2019-02-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75084
Residue number A
94
Residue number B
131
Peptide name
Frizzled-7
Ligandability
Cysteine 94 of Frizzled-7
Cysteine 131 of Frizzled-7
6o3b H 49 H 110
A redox-regulated disulphide may form within Frizzled-7 between cysteines 49 and 110.
Details
Redox score ?
85
PDB code
6o3b
Structure name
crystal structure of frizzled 7 crd in complex with f6 fab
Structure deposition date
2019-02-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75084
Residue number A
49
Residue number B
110
Peptide name
Frizzled-7
Ligandability
Cysteine 49 of Frizzled-7
Cysteine 110 of Frizzled-7
7evw R 336 R 411
A redox-regulated disulphide may form within Frizzled-7 between cysteines 336 and 411.
Details
Redox score ?
84
PDB code
7evw
Structure name
fzd7 -gs complex
Structure deposition date
2021-05-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75084
Residue number A
336
Residue number B
411
Peptide name
Frizzled-7
Ligandability
Cysteine 336 of Frizzled-7
Cysteine 411 of Frizzled-7
5wbs F 90 F 130
A redox-regulated disulphide may form within Frizzled-7 between cysteines 120 and 160 (90 and 130 respectively in this structure).
Details
Redox score ?
83
PDB code
5wbs
Structure name
crystal structure of frizzled-7 crd with an inhibitor peptide fz7-21
Structure deposition date
2017-06-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75084
Residue number A
120
Residue number B
160
Peptide name
Frizzled-7
Ligandability
Cysteine 120 of Frizzled-7
Cysteine 160 of Frizzled-7
5wbs F 27 F 73
A redox-regulated disulphide may form within Frizzled-7 between cysteines 57 and 103 (27 and 73 respectively in this structure).
Details
Redox score ?
82
PDB code
5wbs
Structure name
crystal structure of frizzled-7 crd with an inhibitor peptide fz7-21
Structure deposition date
2017-06-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75084
Residue number A
57
Residue number B
103
Peptide name
Frizzled-7
Ligandability
Cysteine 57 of Frizzled-7
Cysteine 103 of Frizzled-7
7evw R 234 R 315
A redox-regulated disulphide may form within Frizzled-7 between cysteines 234 and 315.
Details
Redox score ?
81
PDB code
7evw
Structure name
fzd7 -gs complex
Structure deposition date
2021-05-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75084
Residue number A
234
Residue number B
315
Peptide name
Frizzled-7
Ligandability
Cysteine 234 of Frizzled-7
Cysteine 315 of Frizzled-7
5wbs H 94 H 118
A redox-regulated disulphide may form within Frizzled-7 between cysteines 124 and 148 (94 and 118 respectively in this structure).
Details
Redox score ?
77
PDB code
5wbs
Structure name
crystal structure of frizzled-7 crd with an inhibitor peptide fz7-21
Structure deposition date
2017-06-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
34
Peptide accession
O75084
Residue number A
124
Residue number B
148
Peptide name
Frizzled-7
Ligandability
Cysteine 124 of Frizzled-7
Cysteine 148 of Frizzled-7
7evw R 264 R 265
A redox-regulated disulphide may form within Frizzled-7 between cysteines 264 and 265. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
7evw
Structure name
fzd7 -gs complex
Structure deposition date
2021-05-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
48
Peptide accession
O75084
Residue number A
264
Residue number B
265
Peptide name
Frizzled-7
Ligandability
Cysteine 264 of Frizzled-7
Cysteine 265 of Frizzled-7
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