ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CLIP-associating protein 2

Intramolecular
Cysteine 157 and cysteine 198
Cysteine 149 and cysteine 696
A redox-regulated disulphide may form within CLIP-associating protein 2 between cysteines 157 and 198. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
3woy
Structure name
crystal structure of clasp2 tog domain (tog2)
Structure deposition date
2014-01-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
92
Peptide accession
O75122
Residue number A
157
Residue number B
198
Peptide name
CLIP-associating protein 2

Ligandability

Cysteine 157 of CLIP-associating protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of CLIP-associating protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CLIP-associating protein 2 between cysteines 149 and 696 (149 and 151 respectively in this structure).

Details

Redox score ?
nan
PDB code
5nr4
Structure name
crystal structure of clasp2 tog1 domain
Structure deposition date
2017-04-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
96
Peptide accession
O75122
Residue number A
149
Residue number B
696
Peptide name
CLIP-associating protein 2

Ligandability

Cysteine 149 of CLIP-associating protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 696 of CLIP-associating protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 in protein A could not be asigned to a Uniprot residue.
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