ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Astrotactin-2

Intramolecular
Cysteine 916 and cysteine 977
Cysteine 1036 and cysteine 1047
Cysteine 1049 and cysteine 1062
Cysteine 825 and cysteine 987
Cysteine 1298 and cysteine 1321
Cysteine 1136 and cysteine 1158
Cysteine 983 and cysteine 990
Cysteine 1190 and cysteine 1277
Cysteine 1047 and cysteine 1062
Cysteine 983 and cysteine 987
More...
Cysteine 1036 and cysteine 1062
Cysteine 987 and cysteine 990
Cysteine 1047 and cysteine 1049
Cysteine 825 and cysteine 990
Cysteine 825 and cysteine 983
Cysteine 1036 and cysteine 1049
Cysteine 916 and cysteine 990
A redox-regulated disulphide may form within Astrotactin-2 between cysteines 916 and 977 (865 and 926 respectively in this structure).

Details

Redox score ?
88
PDB code
5j69
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
916
Residue number B
977
Peptide name
Astrotactin-2

Ligandability

Cysteine 916 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 977 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 1036 and 1047 (985 and 996 respectively in this structure).

Details

Redox score ?
87
PDB code
5j68
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
1036
Residue number B
1047
Peptide name
Astrotactin-2

Ligandability

Cysteine 1036 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1047 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 1049 and 1062 (998 and 1011 respectively in this structure).

Details

Redox score ?
86
PDB code
5j68
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
1049
Residue number B
1062
Peptide name
Astrotactin-2

Ligandability

Cysteine 1049 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1062 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 825 and 987 (774 and 936 respectively in this structure).

Details

Redox score ?
86
PDB code
5j68
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
825
Residue number B
987
Peptide name
Astrotactin-2

Ligandability

Cysteine 825 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 987 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 1298 and 1321 (1247 and 1270 respectively in this structure).

Details

Redox score ?
85
PDB code
5j68
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
1298
Residue number B
1321
Peptide name
Astrotactin-2

Ligandability

Cysteine 1298 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1321 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 1136 and 1158 (1085 and 1107 respectively in this structure).

Details

Redox score ?
83
PDB code
5j68
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
1136
Residue number B
1158
Peptide name
Astrotactin-2

Ligandability

Cysteine 1136 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1158 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 983 and 990 (932 and 939 respectively in this structure).

Details

Redox score ?
83
PDB code
5j68
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
983
Residue number B
990
Peptide name
Astrotactin-2

Ligandability

Cysteine 983 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 990 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 1190 and 1277 (1139 and 1226 respectively in this structure).

Details

Redox score ?
82
PDB code
5j68
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
1190
Residue number B
1277
Peptide name
Astrotactin-2

Ligandability

Cysteine 1190 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1277 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 1047 and 1062 (996 and 1011 respectively in this structure).

Details

Redox score ?
73
PDB code
5j67
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
1047
Residue number B
1062
Peptide name
Astrotactin-2

Ligandability

Cysteine 1047 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1062 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 983 and 987 (932 and 936 respectively in this structure).

Details

Redox score ?
68
PDB code
5j67
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
983
Residue number B
987
Peptide name
Astrotactin-2

Ligandability

Cysteine 983 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 987 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 1036 and 1062 (985 and 1011 respectively in this structure).

Details

Redox score ?
68
PDB code
5j68
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
1036
Residue number B
1062
Peptide name
Astrotactin-2

Ligandability

Cysteine 1036 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1062 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 987 and 990 (936 and 939 respectively in this structure).

Details

Redox score ?
67
PDB code
5j69
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
987
Residue number B
990
Peptide name
Astrotactin-2

Ligandability

Cysteine 987 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 990 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 1047 and 1049 (996 and 998 respectively in this structure).

Details

Redox score ?
66
PDB code
5j68
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
1047
Residue number B
1049
Peptide name
Astrotactin-2

Ligandability

Cysteine 1047 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1049 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 825 and 990 (774 and 939 respectively in this structure).

Details

Redox score ?
65
PDB code
5j69
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
825
Residue number B
990
Peptide name
Astrotactin-2

Ligandability

Cysteine 825 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 990 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 825 and 983 (774 and 932 respectively in this structure).

Details

Redox score ?
63
PDB code
5j69
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
825
Residue number B
983
Peptide name
Astrotactin-2

Ligandability

Cysteine 825 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 983 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 1036 and 1049 (985 and 998 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
5j67
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
1036
Residue number B
1049
Peptide name
Astrotactin-2

Ligandability

Cysteine 1036 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1049 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Astrotactin-2 between cysteines 916 and 990 (865 and 939 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5j67
Structure name
structure of astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development
Structure deposition date
2016-04-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75129
Residue number A
916
Residue number B
990
Peptide name
Astrotactin-2

Ligandability

Cysteine 916 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 990 of Astrotactin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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