ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GATOR complex protein DEPDC5

Intramolecular
Cysteine 737 and cysteine 738
Cysteine 1370 and cysteine 1372
Cysteine 125 and cysteine 153
A redox-regulated disulphide may form within GATOR complex protein DEPDC5 between cysteines 737 and 738. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
6cet
Structure name
cryo-em structure of gator1
Structure deposition date
2018-02-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
38
Minimum pKa ?
8
% buried
23
Peptide accession
O75140
Residue number A
737
Residue number B
738
Peptide name
GATOR complex protein DEPDC5

Ligandability

Cysteine 737 of GATOR complex protein DEPDC5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 738 of GATOR complex protein DEPDC5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GATOR complex protein DEPDC5 between cysteines 1370 and 1372. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7t3a
Structure name
gator1-rag-ragulator - inhibitory complex
Structure deposition date
2021-12-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
100
Peptide accession
O75140
Residue number A
1370
Residue number B
1372
Peptide name
GATOR complex protein DEPDC5

Ligandability

Cysteine 1370 of GATOR complex protein DEPDC5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1372 of GATOR complex protein DEPDC5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GATOR complex protein DEPDC5 between cysteines 125 and 153. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7t3b
Structure name
gator1-rag-ragulator - gap complex
Structure deposition date
2021-12-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
84
Peptide accession
O75140
Residue number A
125
Residue number B
153
Peptide name
GATOR complex protein DEPDC5

Ligandability

Cysteine 125 of GATOR complex protein DEPDC5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 153 of GATOR complex protein DEPDC5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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