ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Autophagy-related protein 13

Intramolecular
Cysteine 81 and cysteine 100
Cysteine 100 and cysteine 187
A redox-regulated disulphide may form within Autophagy-related protein 13 between cysteines 81 and 100.

Details

Redox score ?
69
PDB code
8do8
Structure name
crystal structure atg9 hdir in complex with the atg13:atg101 horma dimer
Structure deposition date
2022-07-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
8
% buried
69
Peptide accession
O75143
Residue number A
81
Residue number B
100
Peptide name
Autophagy-related protein 13

Ligandability

Cysteine 81 of Autophagy-related protein 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of Autophagy-related protein 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Autophagy-related protein 13 between cysteines 100 and 187. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
5c50
Structure name
crystal structure of the complex of human atg101-atg13 horma domain
Structure deposition date
2015-06-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
15
% buried
86
Peptide accession
O75143
Residue number A
100
Residue number B
187
Peptide name
Autophagy-related protein 13

Ligandability

Cysteine 100 of Autophagy-related protein 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Autophagy-related protein 13

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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