ICOS ligand
Intramolecular
Cysteine 158 and cysteine 215
Cysteine 37 and cysteine 113
Cysteine 215 and cysteine 216
Cysteine 37 and cysteine 39
Cysteine 39 and cysteine 113
Cysteine 158 and cysteine 216
6x4g C 158 C 215
A redox-regulated disulphide may form within ICOS ligand between cysteines 158 and 215.
Details
Redox score ?
81
PDB code
6x4g
Structure name
crystal structure of icos in complex with icos-l and an anti icos-l vnar domain
Structure deposition date
2020-05-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75144
Residue number A
158
Residue number B
215
Peptide name
ICOS ligand
Ligandability
Cysteine 158 of ICOS ligand
Cysteine 215 of ICOS ligand
6x4t C 37 C 113
A redox-regulated disulphide may form within ICOS ligand between cysteines 37 and 113.
Details
Redox score ?
79
PDB code
6x4t
Structure name
crystal structure of icos-l in complex with prezalumab and vnar domain
Structure deposition date
2020-05-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75144
Residue number A
37
Residue number B
113
Peptide name
ICOS ligand
Ligandability
Cysteine 37 of ICOS ligand
Cysteine 113 of ICOS ligand
6x4g C 215 C 216
A redox-regulated disulphide may form within ICOS ligand between cysteines 215 and 216. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6x4g
Structure name
crystal structure of icos in complex with icos-l and an anti icos-l vnar domain
Structure deposition date
2020-05-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
nan
Peptide accession
O75144
Residue number A
215
Residue number B
216
Peptide name
ICOS ligand
Ligandability
Cysteine 215 of ICOS ligand
Cysteine 216 of ICOS ligand
6x4g C 37 C 39
A redox-regulated disulphide may form within ICOS ligand between cysteines 37 and 39. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6x4g
Structure name
crystal structure of icos in complex with icos-l and an anti icos-l vnar domain
Structure deposition date
2020-05-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
nan
Peptide accession
O75144
Residue number A
37
Residue number B
39
Peptide name
ICOS ligand
Ligandability
Cysteine 37 of ICOS ligand
Cysteine 39 of ICOS ligand
6x4t C 39 C 113
A redox-regulated disulphide may form within ICOS ligand between cysteines 39 and 113. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6x4t
Structure name
crystal structure of icos-l in complex with prezalumab and vnar domain
Structure deposition date
2020-05-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
nan
Peptide accession
O75144
Residue number A
39
Residue number B
113
Peptide name
ICOS ligand
Ligandability
Cysteine 39 of ICOS ligand
Cysteine 113 of ICOS ligand
6x4g C 158 C 216
A redox-regulated disulphide may form within ICOS ligand between cysteines 158 and 216. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6x4g
Structure name
crystal structure of icos in complex with icos-l and an anti icos-l vnar domain
Structure deposition date
2020-05-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
nan
Peptide accession
O75144
Residue number A
158
Residue number B
216
Peptide name
ICOS ligand
Ligandability
Cysteine 158 of ICOS ligand
Cysteine 216 of ICOS ligand
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