Obscurin-like protein 1
Intramolecular
Cysteine 829 and cysteine 879
Cysteine 920 and cysteine 970
Cysteine 33 and cysteine 84
Cysteine 738 and cysteine 788 L
Cysteine 267 and cysteine 319
Cysteine 879 and cysteine 885
Cysteine 829 and cysteine 885
2lvc A 27 A 77
A redox-regulated disulphide may form within Obscurin-like protein 1 between cysteines 829 and 879 (27 and 77 respectively in this structure).
Details
Redox score ?
74
PDB code
2lvc
Structure name
solution nmr structure of ig like domain (805-892) of obscurin-like protein 1 from homo sapiens, northeast structural genomics consortium (nesg) target hr8578k
Structure deposition date
2012-06-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
67
Peptide accession
O75147
Residue number A
829
Residue number B
879
Peptide name
Obscurin-like protein 1
Ligandability
Cysteine 829 of Obscurin-like protein 1
Cysteine 879 of Obscurin-like protein 1
2cpc A 35 A 85
A redox-regulated disulphide may form within Obscurin-like protein 1 between cysteines 920 and 970 (35 and 85 respectively in this structure).
Details
Redox score ?
74
PDB code
2cpc
Structure name
solution structure of rsgi ruh-030, an ig like domain from human cdna
Structure deposition date
2005-05-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
8
% buried
68
Peptide accession
O75147
Residue number A
920
Residue number B
970
Peptide name
Obscurin-like protein 1
Ligandability
Cysteine 920 of Obscurin-like protein 1
Cysteine 970 of Obscurin-like protein 1
2wwk O 33 O 84
A redox-regulated disulphide may form within Obscurin-like protein 1 between cysteines 33 and 84.
Details
Redox score ?
72
PDB code
2wwk
Structure name
crystal structure of the titin m10-obscurin like 1 ig f17r mutant complex
Structure deposition date
2009-10-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
90
Minimum pKa ?
8
% buried
86
Peptide accession
O75147
Residue number A
33
Residue number B
84
Peptide name
Obscurin-like protein 1
Ligandability
Cysteine 33 of Obscurin-like protein 1
Cysteine 84 of Obscurin-like protein 1
2e6p A 32 A 82
A redox-regulated disulphide may form within Obscurin-like protein 1 between cysteines 738 and 788 (32 and 82 respectively in this structure).
Details
Redox score ?
68
PDB code
2e6p
Structure name
solution structure of the ig-like domain (714-804) from human obscurin-like protein 1
Structure deposition date
2006-12-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
8
% buried
62
Peptide accession
O75147
Residue number A
738
Residue number B
788
Peptide name
Obscurin-like protein 1
Ligandability
Cysteine 738 of Obscurin-like protein 1
Cysteine 788 of Obscurin-like protein 1
5fm5 P 267 P 319
A redox-regulated disulphide may form within Obscurin-like protein 1 between cysteines 267 and 319.
Details
Redox score ?
65
PDB code
5fm5
Structure name
crystal structure of the myomesin:obscurin-like-1 complex
Structure deposition date
2015-11-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
92
Minimum pKa ?
9
% buried
100
Peptide accession
O75147
Residue number A
267
Residue number B
319
Peptide name
Obscurin-like protein 1
Ligandability
Cysteine 267 of Obscurin-like protein 1
Cysteine 319 of Obscurin-like protein 1
2lvc A 77 A 83
A redox-regulated disulphide may form within Obscurin-like protein 1 between cysteines 879 and 885 (77 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
2lvc
Structure name
solution nmr structure of ig like domain (805-892) of obscurin-like protein 1 from homo sapiens, northeast structural genomics consortium (nesg) target hr8578k
Structure deposition date
2012-06-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
42
Peptide accession
O75147
Residue number A
879
Residue number B
885
Peptide name
Obscurin-like protein 1
Ligandability
Cysteine 879 of Obscurin-like protein 1
Cysteine 885 of Obscurin-like protein 1
2lvc A 27 A 83
A redox-regulated disulphide may form within Obscurin-like protein 1 between cysteines 829 and 885 (27 and 83 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
2lvc
Structure name
solution nmr structure of ig like domain (805-892) of obscurin-like protein 1 from homo sapiens, northeast structural genomics consortium (nesg) target hr8578k
Structure deposition date
2012-06-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
9
% buried
36
Peptide accession
O75147
Residue number A
829
Residue number B
885
Peptide name
Obscurin-like protein 1
Ligandability
Cysteine 829 of Obscurin-like protein 1
Cysteine 885 of Obscurin-like protein 1
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