ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lysine-specific demethylase 4A

Intramolecular
Cysteine 306 and cysteine 308
Cysteine 234 and cysteine 306
Cysteine 234 and cysteine 308
A redox-regulated disulphide may form within Lysine-specific demethylase 4A between cysteines 306 and 308 (307 and 309 respectively in this structure).

Details

Redox score ?
89
PDB code
5fpv
Structure name
crystal structure of human jmjd2a in complex with compound kdoam20a
Structure deposition date
2015-12-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
49
Minimum pKa ?
7
% buried
4
Peptide accession
O75164
Residue number A
306
Residue number B
308
Peptide name
Lysine-specific demethylase 4A

Ligandability

Cysteine 306 of Lysine-specific demethylase 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of Lysine-specific demethylase 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysine-specific demethylase 4A between cysteines 234 and 306.

Details

Redox score ?
89
PDB code
5tvs
Structure name
jmjd2a in complex with ni(ii)
Structure deposition date
2016-11-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
10
Peptide accession
O75164
Residue number A
234
Residue number B
306
Peptide name
Lysine-specific demethylase 4A

Ligandability

Cysteine 234 of Lysine-specific demethylase 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Lysine-specific demethylase 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysine-specific demethylase 4A between cysteines 234 and 308.

Details

Redox score ?
86
PDB code
5tvr
Structure name
jmjd2a in complex with ni(ii) and alpha-ketoglutarate
Structure deposition date
2016-11-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
6
Peptide accession
O75164
Residue number A
234
Residue number B
308
Peptide name
Lysine-specific demethylase 4A

Ligandability

Cysteine 234 of Lysine-specific demethylase 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of Lysine-specific demethylase 4A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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