Xylulose kinase
Intramolecular
Cysteine 233 and cysteine 237
Cysteine 9 and cysteine 10
Cysteine 10 and cysteine 272
Cysteine 9 and cysteine 272
Cysteine 146 and cysteine 237
4bc4 B 233 B 237
A redox-regulated disulphide may form within Xylulose kinase between cysteines 233 and 237. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4bc4
Structure name
crystal structure of human d-xylulokinase in complex with d-xylulose
Structure deposition date
2012-10-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
88
Peptide accession
O75191
Residue number A
233
Residue number B
237
Peptide name
Xylulose kinase
Ligandability
Cysteine 233 of Xylulose kinase
Cysteine 237 of Xylulose kinase
4bc2 A 9 A 10
A redox-regulated disulphide may form within Xylulose kinase between cysteines 9 and 10. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
4bc2
Structure name
crystal structure of human d-xylulokinase in complex with d-xylulose and adenosine diphosphate
Structure deposition date
2012-10-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
84
Peptide accession
O75191
Residue number A
9
Residue number B
10
Peptide name
Xylulose kinase
Ligandability
Cysteine 9 of Xylulose kinase
Cysteine 10 of Xylulose kinase
4bc5 A 10 A 272
A redox-regulated disulphide may form within Xylulose kinase between cysteines 10 and 272. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
4bc5
Structure name
crystal structure of human d-xylulokinase in complex with inhibitor 5-deoxy-5-fluoro-d-xylulose
Structure deposition date
2012-10-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
88
Peptide accession
O75191
Residue number A
10
Residue number B
272
Peptide name
Xylulose kinase
Ligandability
Cysteine 10 of Xylulose kinase
Cysteine 272 of Xylulose kinase
4bc2 C 9 C 272
A redox-regulated disulphide may form within Xylulose kinase between cysteines 9 and 272. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
4bc2
Structure name
crystal structure of human d-xylulokinase in complex with d-xylulose and adenosine diphosphate
Structure deposition date
2012-10-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
80
Peptide accession
O75191
Residue number A
9
Residue number B
272
Peptide name
Xylulose kinase
Ligandability
Cysteine 9 of Xylulose kinase
Cysteine 272 of Xylulose kinase
4bc2 A 146 A 237
A redox-regulated disulphide may form within Xylulose kinase between cysteines 146 and 237. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
4bc2
Structure name
crystal structure of human d-xylulokinase in complex with d-xylulose and adenosine diphosphate
Structure deposition date
2012-10-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
85
Peptide accession
O75191
Residue number A
146
Residue number B
237
Peptide name
Xylulose kinase
Ligandability
Cysteine 146 of Xylulose kinase
Cysteine 237 of Xylulose kinase
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