ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glycine receptor subunit alpha-3

Intramolecular
Cysteine 171 and cysteine 185
Cysteine 231 and cysteine 242
A redox-regulated disulphide may form within Glycine receptor subunit alpha-3 between cysteines 171 and 185 (138 and 152 respectively in this structure).

Details

Redox score ?
84
PDB code
5tin
Structure name
crystal structure of human glycine receptor alpha-3 mutant n38q bound to am-3607
Structure deposition date
2016-10-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75311
Residue number A
171
Residue number B
185
Peptide name
Glycine receptor subunit alpha-3

Ligandability

Cysteine 171 of Glycine receptor subunit alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 185 of Glycine receptor subunit alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glycine receptor subunit alpha-3 between cysteines 231 and 242 (198 and 209 respectively in this structure).

Details

Redox score ?
83
PDB code
5vdi
Structure name
crystal structure of human glycine receptor alpha-3 mutant n38q bound to am-3607, glycine, and ivermectin
Structure deposition date
2017-04-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75311
Residue number A
231
Residue number B
242
Peptide name
Glycine receptor subunit alpha-3

Ligandability

Cysteine 231 of Glycine receptor subunit alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 242 of Glycine receptor subunit alpha-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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