Ubiquitin carboxyl-terminal hydrolase 12
Intermolecular
Cysteine 200 of WD repeat-containing protein 48 and cysteine 48
Intramolecular
Cysteine 186 and cysteine 236
Cysteine 186 and cysteine 189
Cysteine 186 and cysteine 233
Cysteine 189 and cysteine 236
Cysteine 189 and cysteine 233
Cysteine 233 and cysteine 236
Cysteine 48 and cysteine 309
Cysteine 48 and cysteine 50
5k1a D 200 E 52
A redox-regulated disulphide may form between cysteine 200 of WD repeat-containing protein 48 and cysteine 48 of Ubiquitin carboxyl-terminal hydrolase 12 (200 and 52 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
5k1a
Structure name
crystal structure of the uaf1-usp12 complex in c2 space group
Structure deposition date
2016-05-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
72
Peptide A name
WD repeat-containing protein 48
Peptide B name
Ubiquitin carboxyl-terminal hydrolase 12
Peptide A accession
Q8TAF3
Peptide B accession
O75317
Peptide A residue number
200
Peptide B residue number
48
Ligandability
Cysteine 200 of WD repeat-containing protein 48
Cysteine 48 of Ubiquitin carboxyl-terminal hydrolase 12
5k16 A 186 A 236
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 12 between cysteines 186 and 236.
Details
Redox score ?
89
PDB code
5k16
Structure name
crystal structure of free ubiquitin-specific protease 12
Structure deposition date
2016-05-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
2
Peptide accession
O75317
Residue number A
186
Residue number B
236
Peptide name
Ubiquitin carboxyl-terminal hydrolase 12
Ligandability
Cysteine 186 of Ubiquitin carboxyl-terminal hydrolase 12
Cysteine 236 of Ubiquitin carboxyl-terminal hydrolase 12
5k1b A 186 A 189
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 12 between cysteines 186 and 189.
Details
Redox score ?
88
PDB code
5k1b
Structure name
crystal structure of the uaf1/usp12 complex in f222 space group
Structure deposition date
2016-05-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
3
% buried
76
Peptide accession
O75317
Residue number A
186
Residue number B
189
Peptide name
Ubiquitin carboxyl-terminal hydrolase 12
Ligandability
Cysteine 186 of Ubiquitin carboxyl-terminal hydrolase 12
Cysteine 189 of Ubiquitin carboxyl-terminal hydrolase 12
5k1c A 186 A 233
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 12 between cysteines 186 and 233.
Details
Redox score ?
81
PDB code
5k1c
Structure name
crystal structure of the uaf1/wdr20/usp12 complex
Structure deposition date
2016-05-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75317
Residue number A
186
Residue number B
233
Peptide name
Ubiquitin carboxyl-terminal hydrolase 12
Ligandability
Cysteine 186 of Ubiquitin carboxyl-terminal hydrolase 12
Cysteine 233 of Ubiquitin carboxyl-terminal hydrolase 12
5k1b A 189 A 236
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 12 between cysteines 189 and 236.
Details
Redox score ?
71
PDB code
5k1b
Structure name
crystal structure of the uaf1/usp12 complex in f222 space group
Structure deposition date
2016-05-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
nan
Peptide accession
O75317
Residue number A
189
Residue number B
236
Peptide name
Ubiquitin carboxyl-terminal hydrolase 12
Ligandability
Cysteine 189 of Ubiquitin carboxyl-terminal hydrolase 12
Cysteine 236 of Ubiquitin carboxyl-terminal hydrolase 12
5k1a A 189 A 233
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 12 between cysteines 189 and 233.
Details
Redox score ?
68
PDB code
5k1a
Structure name
crystal structure of the uaf1-usp12 complex in c2 space group
Structure deposition date
2016-05-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
13
% buried
nan
Peptide accession
O75317
Residue number A
189
Residue number B
233
Peptide name
Ubiquitin carboxyl-terminal hydrolase 12
Ligandability
Cysteine 189 of Ubiquitin carboxyl-terminal hydrolase 12
Cysteine 233 of Ubiquitin carboxyl-terminal hydrolase 12
5l8w A 233 A 236
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 12 between cysteines 233 and 236. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
5l8w
Structure name
structure of usp12-ub-prg/uaf1
Structure deposition date
2016-06-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
23
% buried
nan
Peptide accession
O75317
Residue number A
233
Residue number B
236
Peptide name
Ubiquitin carboxyl-terminal hydrolase 12
Ligandability
Cysteine 233 of Ubiquitin carboxyl-terminal hydrolase 12
Cysteine 236 of Ubiquitin carboxyl-terminal hydrolase 12
5k16 A 48 A 309
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 12 between cysteines 48 and 309. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
5k16
Structure name
crystal structure of free ubiquitin-specific protease 12
Structure deposition date
2016-05-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
77
Peptide accession
O75317
Residue number A
48
Residue number B
309
Peptide name
Ubiquitin carboxyl-terminal hydrolase 12
Ligandability
Cysteine 48 of Ubiquitin carboxyl-terminal hydrolase 12
Cysteine 309 of Ubiquitin carboxyl-terminal hydrolase 12
5k1a E 52 E 54
A redox-regulated disulphide may form within Ubiquitin carboxyl-terminal hydrolase 12 between cysteines 48 and 50 (52 and 54 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
5k1a
Structure name
crystal structure of the uaf1-usp12 complex in c2 space group
Structure deposition date
2016-05-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
56
Peptide accession
O75317
Residue number A
48
Residue number B
50
Peptide name
Ubiquitin carboxyl-terminal hydrolase 12
Ligandability
Cysteine 48 of Ubiquitin carboxyl-terminal hydrolase 12
Cysteine 50 of Ubiquitin carboxyl-terminal hydrolase 12
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