ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc finger protein 217

Intramolecular
Cysteine 501 and cysteine 504
Cysteine 473 and cysteine 476
A redox-regulated disulphide may form within Zinc finger protein 217 between cysteines 501 and 504.

Details

Redox score ?
88
PDB code
4is1
Structure name
crystal structure of znf217 bound to dna
Structure deposition date
2013-01-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
37
Minimum pKa ?
7
% buried
0
Peptide accession
O75362
Residue number A
501
Residue number B
504
Peptide name
Zinc finger protein 217

Ligandability

Cysteine 501 of Zinc finger protein 217

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 504 of Zinc finger protein 217

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 217 between cysteines 473 and 476.

Details

Redox score ?
88
PDB code
3uk3
Structure name
crystal structure of znf217 bound to dna
Structure deposition date
2011-11-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
6
% buried
2
Peptide accession
O75362
Residue number A
473
Residue number B
476
Peptide name
Zinc finger protein 217

Ligandability

Cysteine 473 of Zinc finger protein 217

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 476 of Zinc finger protein 217

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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