a tool for identifying drug-targetable redox-active disulphides

Protein tyrosine phosphatase type IVA 3

Intramolecular

Cysteine 49 and cysteine 104

A redox-regulated disulphide may form within Protein tyrosine phosphatase type IVA 3 between cysteines 49 and 104 (52 and 107 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

39

PDB code

Structure name

solution structure of human prl-3

Structure deposition date

2003-10-15

Thiol separation (Å)

9

Half-sphere exposure sum ?

64

Minimum pK_a ?

10

% buried

34

Peptide accession

Residue number A

49

Residue number B

104

Peptide name

Protein tyrosine phosphatase type IVA 3

Ligandability

Cysteine 49 of Protein tyrosine phosphatase type IVA 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Protein tyrosine phosphatase type IVA 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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