ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Citrate synthase, mitochondrial

Intramolecular
Cysteine 211 and cysteine 500
Cysteine 101 and cysteine 359
A redox-regulated disulphide may form within Citrate synthase, mitochondrial between cysteines 211 and 500 (184 and 500 respectively in this structure).

Details

Redox score ?
85
PDB code
3enj
Structure name
structure of pig heart citrate synthase at 1
Structure deposition date
2008-09-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P00889
Residue number A
211
Residue number B
500
Peptide name
Citrate synthase, mitochondrial

Ligandability

Cysteine 211 of Citrate synthase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 500 of Citrate synthase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 500 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Citrate synthase, mitochondrial between cysteines 101 and 359. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
5uzr
Structure name
crystal structure of citrate synthase from homo sapiens
Structure deposition date
2017-02-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
92
Peptide accession
O75390
Residue number A
101
Residue number B
359
Peptide name
Citrate synthase, mitochondrial

Ligandability

Cysteine 101 of Citrate synthase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 359 of Citrate synthase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: