ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cell division control protein 45 homolog

Intramolecular
Cysteine 433 and cysteine 448
Cysteine 433 and cysteine 435
Cysteine 31 and cysteine 33
Cysteine 77 and cysteine 98
A redox-regulated disulphide may form within Cell division control protein 45 homolog between cysteines 433 and 448.

Details

Redox score ?
76
PDB code
5dgo
Structure name
crystal structure of cell division cycle protein 45 (cdc45)
Structure deposition date
2015-08-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
8
% buried
76
Peptide accession
O75419
Residue number A
433
Residue number B
448
Peptide name
Cell division control protein 45 homolog

Ligandability

Cysteine 433 of Cell division control protein 45 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 448 of Cell division control protein 45 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cell division control protein 45 homolog between cysteines 433 and 435. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5dgo
Structure name
crystal structure of cell division cycle protein 45 (cdc45)
Structure deposition date
2015-08-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
41
Peptide accession
O75419
Residue number A
433
Residue number B
435
Peptide name
Cell division control protein 45 homolog

Ligandability

Cysteine 433 of Cell division control protein 45 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 435 of Cell division control protein 45 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cell division control protein 45 homolog between cysteines 31 and 33. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
22
PDB code
5dgo
Structure name
crystal structure of cell division cycle protein 45 (cdc45)
Structure deposition date
2015-08-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
97
Minimum pKa ?
12
% buried
100
Peptide accession
O75419
Residue number A
31
Residue number B
33
Peptide name
Cell division control protein 45 homolog

Ligandability

Cysteine 31 of Cell division control protein 45 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 33 of Cell division control protein 45 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cell division control protein 45 homolog between cysteines 77 and 98. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
21
PDB code
5dgo
Structure name
crystal structure of cell division cycle protein 45 (cdc45)
Structure deposition date
2015-08-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
100
Peptide accession
O75419
Residue number A
77
Residue number B
98
Peptide name
Cell division control protein 45 homolog

Ligandability

Cysteine 77 of Cell division control protein 45 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Cell division control protein 45 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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