Mediator of RNA polymerase II transcription subunit 24
Intermolecular
Cysteine 464 of Mediator of RNA polymerase II transcription subunit 1 and cysteine 93
Intramolecular
Cysteine 355 and cysteine 357
Cysteine 110 and cysteine 117
Cysteine 134 and cysteine 161 L
Cysteine 355 and cysteine 359
Cysteine 532 and cysteine 546
Cysteine 578 and cysteine 619
Cysteine 161 and cysteine 164
Cysteine 134 and cysteine 164 L
Cysteine 117 and cysteine 121
More...Cysteine 105 and cysteine 164
Cysteine 357 and cysteine 359
Cysteine 931 and cysteine 934
Cysteine 773 and cysteine 816
Cysteine 745 and cysteine 816
Cysteine 501 and cysteine 619
Cysteine 501 and cysteine 578
Cysteine 532 and cysteine 578
Cysteine 164 and cysteine 218
Cysteine 161 and cysteine 218
Cysteine 532 and cysteine 619
Cysteine 110 and cysteine 121
7enj A 464 X 93
A redox-regulated disulphide may form between cysteine 464 of Mediator of RNA polymerase II transcription subunit 1 and cysteine 93 of Mediator of RNA polymerase II transcription subunit 24. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
90
Peptide A name
Mediator of RNA polymerase II transcription subunit 1
Peptide B name
Mediator of RNA polymerase II transcription subunit 24
Peptide A accession
Q15648
Peptide B accession
O75448
Peptide A residue number
464
Peptide B residue number
93
Ligandability
Cysteine 464 of Mediator of RNA polymerase II transcription subunit 1
Cysteine 93 of Mediator of RNA polymerase II transcription subunit 24
7enj X 355 X 357
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 355 and 357.
Details
Redox score ?
87
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
3
% buried
56
Peptide accession
O75448
Residue number A
355
Residue number B
357
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 355 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 357 of Mediator of RNA polymerase II transcription subunit 24
7emf X 110 X 117
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 110 and 117.
Details
Redox score ?
78
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
7
% buried
60
Peptide accession
O75448
Residue number A
110
Residue number B
117
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 110 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 117 of Mediator of RNA polymerase II transcription subunit 24
7enj X 134 X 161
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 134 and 161.
Details
Redox score ?
74
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
78
Minimum pKa ?
9
% buried
94
Peptide accession
O75448
Residue number A
134
Residue number B
161
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 134 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 161 of Mediator of RNA polymerase II transcription subunit 24
7emf X 355 X 359
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 355 and 359.
Details
Redox score ?
74
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
90
Peptide accession
O75448
Residue number A
355
Residue number B
359
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 355 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 359 of Mediator of RNA polymerase II transcription subunit 24
7enj X 532 X 546
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 532 and 546.
Details
Redox score ?
73
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
8
% buried
79
Peptide accession
O75448
Residue number A
532
Residue number B
546
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 532 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 546 of Mediator of RNA polymerase II transcription subunit 24
7emf X 578 X 619
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 578 and 619.
Details
Redox score ?
68
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
9
% buried
100
Peptide accession
O75448
Residue number A
578
Residue number B
619
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 578 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 619 of Mediator of RNA polymerase II transcription subunit 24
6w1s S 161 S 164
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 161 and 164.
Details
Redox score ?
61
PDB code
6w1s
Structure name
atomic model of the mammalian mediator complex
Structure deposition date
2020-03-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
nan
Peptide accession
Q99K74
Residue number A
161
Residue number B
164
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 161 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 164 of Mediator of RNA polymerase II transcription subunit 24
6w1s S 134 S 164
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 134 and 164. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
6w1s
Structure name
atomic model of the mammalian mediator complex
Structure deposition date
2020-03-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
nan
Peptide accession
Q99K74
Residue number A
134
Residue number B
164
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 134 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 164 of Mediator of RNA polymerase II transcription subunit 24
7enj X 117 X 121
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 117 and 121. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
7
% buried
74
Peptide accession
O75448
Residue number A
117
Residue number B
121
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 117 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 121 of Mediator of RNA polymerase II transcription subunit 24
6w1s S 105 S 164
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 105 and 164. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6w1s
Structure name
atomic model of the mammalian mediator complex
Structure deposition date
2020-03-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
64
Peptide accession
Q99K74
Residue number A
105
Residue number B
164
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 105 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 164 of Mediator of RNA polymerase II transcription subunit 24
7enj X 357 X 359
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 357 and 359. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
60
Minimum pKa ?
16
% buried
68
Peptide accession
O75448
Residue number A
357
Residue number B
359
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 357 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 359 of Mediator of RNA polymerase II transcription subunit 24
7enj X 931 X 934
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 931 and 934. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
12
% buried
84
Peptide accession
O75448
Residue number A
931
Residue number B
934
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 931 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 934 of Mediator of RNA polymerase II transcription subunit 24
7enj X 773 X 816
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 773 and 816. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
100
Peptide accession
O75448
Residue number A
773
Residue number B
816
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 773 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 816 of Mediator of RNA polymerase II transcription subunit 24
7enj X 745 X 816
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 745 and 816. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
13
% buried
100
Peptide accession
O75448
Residue number A
745
Residue number B
816
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 745 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 816 of Mediator of RNA polymerase II transcription subunit 24
7emf X 501 X 619
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 501 and 619. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
13
% buried
100
Peptide accession
O75448
Residue number A
501
Residue number B
619
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 501 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 619 of Mediator of RNA polymerase II transcription subunit 24
7emf X 501 X 578
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 501 and 578. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
100
Peptide accession
O75448
Residue number A
501
Residue number B
578
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 501 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 578 of Mediator of RNA polymerase II transcription subunit 24
7enj X 532 X 578
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 532 and 578. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
94
Peptide accession
O75448
Residue number A
532
Residue number B
578
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 532 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 578 of Mediator of RNA polymerase II transcription subunit 24
6w1s S 164 S 218
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 164 and 218. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6w1s
Structure name
atomic model of the mammalian mediator complex
Structure deposition date
2020-03-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
56
Peptide accession
Q99K74
Residue number A
164
Residue number B
218
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 164 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 218 of Mediator of RNA polymerase II transcription subunit 24
6w1s S 161 S 218
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 161 and 218. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
6w1s
Structure name
atomic model of the mammalian mediator complex
Structure deposition date
2020-03-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
nan
Peptide accession
Q99K74
Residue number A
161
Residue number B
218
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 161 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 218 of Mediator of RNA polymerase II transcription subunit 24
7enj X 532 X 619
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 532 and 619. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
16
% buried
94
Peptide accession
O75448
Residue number A
532
Residue number B
619
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 532 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 619 of Mediator of RNA polymerase II transcription subunit 24
7enj X 110 X 121
A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 24 between cysteines 110 and 121. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
7enj
Structure name
human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)
Structure deposition date
2021-04-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
13
% buried
76
Peptide accession
O75448
Residue number A
110
Residue number B
121
Peptide name
Mediator of RNA polymerase II transcription subunit 24
Ligandability
Cysteine 110 of Mediator of RNA polymerase II transcription subunit 24
Cysteine 121 of Mediator of RNA polymerase II transcription subunit 24
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