Leucine-rich repeat-containing G-protein coupled receptor 5
Intramolecular
Cysteine 34 and cysteine 40
Cysteine 479 and cysteine 906
Cysteine 38 and cysteine 52
Cysteine 479 and cysteine 541
Cysteine 348 and cysteine 373
Cysteine 38 and cysteine 40
Cysteine 480 and cysteine 485
Cysteine 34 and cysteine 38
Cysteine 34 and cysteine 52
Cysteine 479 and cysteine 485
More...Cysteine 485 and cysteine 541
Cysteine 485 and cysteine 906
Cysteine 480 and cysteine 541
Cysteine 40 and cysteine 52
Cysteine 479 and cysteine 480
Cysteine 480 and cysteine 906
4bsr A 34 A 40
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 34 and 40.
Details
Redox score ?
88
PDB code
4bsr
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p22121 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75473
Residue number A
34
Residue number B
40
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 34 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 40 of Leucine-rich repeat-containing G-protein coupled receptor 5
4bst A 479 A 541
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 479 and 906 (479 and 541 respectively in this structure).
Details
Redox score ?
87
PDB code
4bst
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p6122 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75473
Residue number A
479
Residue number B
906
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 479 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 906 of Leucine-rich repeat-containing G-protein coupled receptor 5
4bsu A 38 A 52
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 38 and 52.
Details
Redox score ?
85
PDB code
4bsu
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in c2 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75473
Residue number A
38
Residue number B
52
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 38 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 52 of Leucine-rich repeat-containing G-protein coupled receptor 5
4bsr A 479 A 541
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 479 and 541.
Details
Redox score ?
85
PDB code
4bsr
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p22121 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75473
Residue number A
479
Residue number B
541
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 479 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 541 of Leucine-rich repeat-containing G-protein coupled receptor 5
4bst B 348 B 373
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 348 and 373.
Details
Redox score ?
84
PDB code
4bst
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p6122 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75473
Residue number A
348
Residue number B
373
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 348 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 373 of Leucine-rich repeat-containing G-protein coupled receptor 5
4bsu B 38 B 40
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 38 and 40.
Details
Redox score ?
75
PDB code
4bsu
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in c2 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
5
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75473
Residue number A
38
Residue number B
40
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 38 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 40 of Leucine-rich repeat-containing G-protein coupled receptor 5
4ufs A 480 A 485
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 480 and 485.
Details
Redox score ?
66
PDB code
4ufs
Structure name
low resolution structure r-spondin-2 (fu1fu2) in complex with the ectodomains of lgr5 and znrf3
Structure deposition date
2015-03-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
O75473
Residue number A
480
Residue number B
485
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 480 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 485 of Leucine-rich repeat-containing G-protein coupled receptor 5
4bsu E 34 E 38
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 34 and 38.
Details
Redox score ?
63
PDB code
4bsu
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in c2 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75473
Residue number A
34
Residue number B
38
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 34 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 38 of Leucine-rich repeat-containing G-protein coupled receptor 5
4bsr B 34 B 52
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 34 and 52. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
4bsr
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p22121 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75473
Residue number A
34
Residue number B
52
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 34 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 52 of Leucine-rich repeat-containing G-protein coupled receptor 5
4ufr A 479 A 485
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 479 and 485. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4ufr
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-2 (fu1fu2)
Structure deposition date
2015-03-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75473
Residue number A
479
Residue number B
485
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 479 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 485 of Leucine-rich repeat-containing G-protein coupled receptor 5
4bsu E 485 E 541
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 485 and 541. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
4bsu
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in c2 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
nan
Peptide accession
O75473
Residue number A
485
Residue number B
541
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 485 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 541 of Leucine-rich repeat-containing G-protein coupled receptor 5
4ufr A 485 A 541
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 485 and 906 (485 and 541 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
4ufr
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-2 (fu1fu2)
Structure deposition date
2015-03-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75473
Residue number A
485
Residue number B
906
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 485 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 906 of Leucine-rich repeat-containing G-protein coupled receptor 5
4bss E 480 E 541
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 480 and 541. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
4bss
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p21 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
nan
Peptide accession
O75473
Residue number A
480
Residue number B
541
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 480 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 541 of Leucine-rich repeat-containing G-protein coupled receptor 5
4bst B 40 B 52
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 40 and 52. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
4bst
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p6122 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75473
Residue number A
40
Residue number B
52
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 40 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 52 of Leucine-rich repeat-containing G-protein coupled receptor 5
4ufs A 479 A 480
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 479 and 480. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
4ufs
Structure name
low resolution structure r-spondin-2 (fu1fu2) in complex with the ectodomains of lgr5 and znrf3
Structure deposition date
2015-03-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
nan
Peptide accession
O75473
Residue number A
479
Residue number B
480
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 479 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 480 of Leucine-rich repeat-containing G-protein coupled receptor 5
4ufr A 480 A 541
A redox-regulated disulphide may form within Leucine-rich repeat-containing G-protein coupled receptor 5 between cysteines 480 and 906 (480 and 541 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
4ufr
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-2 (fu1fu2)
Structure deposition date
2015-03-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75473
Residue number A
480
Residue number B
906
Peptide name
Leucine-rich repeat-containing G-protein coupled receptor 5
Ligandability
Cysteine 480 of Leucine-rich repeat-containing G-protein coupled receptor 5
Cysteine 906 of Leucine-rich repeat-containing G-protein coupled receptor 5
If this tool was useful for finding a disulphide, please cite: