a tool for identifying drug-targetable redox-active disulphides

Transcriptional adapter 2-alpha

Intramolecular

Cysteine 103 and cysteine 110

A redox-regulated disulphide may form within Transcriptional adapter 2-alpha between cysteines 103 and 110 (39 and 46 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

52

PDB code

Structure name

solution structure of the myb-like dna binding domain of human transcriptional adaptor 2-like, isoform b

Structure deposition date

2005-05-12

Thiol separation (Å)

8

Half-sphere exposure sum ?

55

Minimum pK_a ?

9

% buried

14

Peptide accession

Residue number A

103

Residue number B

110

Peptide name

Transcriptional adapter 2-alpha

Ligandability

Cysteine 103 of Transcriptional adapter 2-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Transcriptional adapter 2-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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