ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Polycomb protein EED

Intramolecular
Cysteine 409 and cysteine 429
Cysteine 84 and cysteine 409
Cysteine 78 and cysteine 401
Cysteine 324 and cysteine 361 L
Cysteine 254 and cysteine 311
Cysteine 311 and cysteine 361 L
Cysteine 84 and cysteine 429
A redox-regulated disulphide may form within Polycomb protein EED between cysteines 409 and 429.

Details

Redox score ?
72
PDB code
7kxt
Structure name
crystal structure of human eed
Structure deposition date
2020-12-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75530
Residue number A
409
Residue number B
429
Peptide name
Polycomb protein EED

Ligandability

Cysteine 409 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 429 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polycomb protein EED between cysteines 84 and 409.

Details

Redox score ?
61
PDB code
7si4
Structure name
crystal structure of eed with mrtx-2219
Structure deposition date
2021-10-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
54
Peptide accession
O75530
Residue number A
84
Residue number B
409
Peptide name
Polycomb protein EED

Ligandability

Cysteine 84 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 409 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polycomb protein EED between cysteines 78 and 401. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
5ls6
Structure name
structure of human polycomb repressive complex 2 (prc2) with inhibitor
Structure deposition date
2016-08-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
37
Peptide accession
O75530
Residue number A
78
Residue number B
401
Peptide name
Polycomb protein EED

Ligandability

Cysteine 78 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 401 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polycomb protein EED between cysteines 324 and 361. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
5u5t
Structure name
crystal structure of eed in complex with h3k27me3 peptide and 3- (benzo[d][1,3]dioxol-4-ylmethyl)piperidine-1-carboximidamide
Structure deposition date
2016-12-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75530
Residue number A
324
Residue number B
361
Peptide name
Polycomb protein EED

Ligandability

Cysteine 324 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polycomb protein EED between cysteines 254 and 311 (253 and 303 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2qxv
Structure name
structural basis of ezh2 recognition by eed
Structure deposition date
2007-08-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
90
Minimum pKa ?
10
% buried
100
Peptide accession
Q921E6
Residue number A
254
Residue number B
311
Peptide name
Polycomb protein EED

Ligandability

Cysteine 254 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 311 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polycomb protein EED between cysteines 311 and 361 (303 and 353 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
2qxv
Structure name
structural basis of ezh2 recognition by eed
Structure deposition date
2007-08-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
92
Peptide accession
Q921E6
Residue number A
311
Residue number B
361
Peptide name
Polycomb protein EED

Ligandability

Cysteine 311 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polycomb protein EED between cysteines 84 and 429. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7msd
Structure name
structure of eed bound to eedi-6068
Structure deposition date
2021-05-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
65
Peptide accession
O75530
Residue number A
84
Residue number B
429
Peptide name
Polycomb protein EED

Ligandability

Cysteine 84 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 429 of Polycomb protein EED

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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