Splicing factor 3B subunit 1
Intermolecular
Cysteine 677 and cysteine 11 of PHD finger-like domain-containing protein 5A
Cysteine 677 and cysteine 85 of PHD finger-like domain-containing protein 5A
Cysteine 677 and cysteine 46 of PHD finger-like domain-containing protein 5A L
Cysteine 677 and cysteine 49 of PHD finger-like domain-containing protein 5A L
Cysteine 1244 and cysteine 1054 of Splicing factor 3B subunit 3 L
Intramolecular
Cysteine 795 and cysteine 796 L
Cysteine 933 and cysteine 965
5z58 1 677 6 11
A redox-regulated disulphide may form between cysteine 677 of Splicing factor 3B subunit 1 and cysteine 11 of PHD finger-like domain-containing protein 5A. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
5z58
Structure name
cryo-em structure of a human activated spliceosome (early bact) at 4
Structure deposition date
2018-01-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
64
Peptide A name
Splicing factor 3B subunit 1
Peptide B name
PHD finger-like domain-containing protein 5A
Peptide A accession
O75533
Peptide B accession
Q7RTV0
Peptide A residue number
677
Peptide B residue number
11
Ligandability
Cysteine 677 of Splicing factor 3B subunit 1
Cysteine 11 of PHD finger-like domain-containing protein 5A
5z58 1 677 6 85
A redox-regulated disulphide may form between cysteine 677 of Splicing factor 3B subunit 1 and cysteine 85 of PHD finger-like domain-containing protein 5A. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
5z58
Structure name
cryo-em structure of a human activated spliceosome (early bact) at 4
Structure deposition date
2018-01-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
6
% buried
70
Peptide A name
Splicing factor 3B subunit 1
Peptide B name
PHD finger-like domain-containing protein 5A
Peptide A accession
O75533
Peptide B accession
Q7RTV0
Peptide A residue number
677
Peptide B residue number
85
Ligandability
Cysteine 677 of Splicing factor 3B subunit 1
Cysteine 85 of PHD finger-like domain-containing protein 5A
7q4o A 677 G 46
A redox-regulated disulphide may form between cysteine 677 of Splicing factor 3B subunit 1 and cysteine 46 of PHD finger-like domain-containing protein 5A. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7q4o
Structure name
substrate-bound a-like u2 snrnp
Structure deposition date
2021-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
48
Peptide A name
Splicing factor 3B subunit 1
Peptide B name
PHD finger-like domain-containing protein 5A
Peptide A accession
O75533
Peptide B accession
Q7RTV0
Peptide A residue number
677
Peptide B residue number
46
Ligandability
Cysteine 677 of Splicing factor 3B subunit 1
Cysteine 46 of PHD finger-like domain-containing protein 5A
7q4o A 677 G 49
A redox-regulated disulphide may form between cysteine 677 of Splicing factor 3B subunit 1 and cysteine 49 of PHD finger-like domain-containing protein 5A. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7q4o
Structure name
substrate-bound a-like u2 snrnp
Structure deposition date
2021-11-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
42
Peptide A name
Splicing factor 3B subunit 1
Peptide B name
PHD finger-like domain-containing protein 5A
Peptide A accession
O75533
Peptide B accession
Q7RTV0
Peptide A residue number
677
Peptide B residue number
49
Ligandability
Cysteine 677 of Splicing factor 3B subunit 1
Cysteine 49 of PHD finger-like domain-containing protein 5A
6ff4 u 1244 v 1054
A redox-regulated disulphide may form between cysteine 1244 of Splicing factor 3B subunit 1 and cysteine 1054 of Splicing factor 3B subunit 3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
27
PDB code
6ff4
Structure name
human bact spliceosome core structure
Structure deposition date
2018-01-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
85
Minimum pKa ?
11
% buried
100
Peptide A name
Splicing factor 3B subunit 1
Peptide B name
Splicing factor 3B subunit 3
Peptide A accession
O75533
Peptide B accession
Q15393
Peptide A residue number
1244
Peptide B residue number
1054
Ligandability
Cysteine 1244 of Splicing factor 3B subunit 1
Cysteine 1054 of Splicing factor 3B subunit 3
7b9c C 795 C 796
A redox-regulated disulphide may form within Splicing factor 3B subunit 1 between cysteines 795 and 796.
Details
Redox score ?
68
PDB code
7b9c
Structure name
structure of a minimal sf3b core in complex with spliceostatin a (form i)
Structure deposition date
2020-12-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
8
% buried
100
Peptide accession
O75533
Residue number A
795
Residue number B
796
Peptide name
Splicing factor 3B subunit 1
Ligandability
Cysteine 795 of Splicing factor 3B subunit 1
Cysteine 796 of Splicing factor 3B subunit 1
6en4 C 933 C 965
A redox-regulated disulphide may form within Splicing factor 3B subunit 1 between cysteines 933 and 965. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6en4
Structure name
sf3b core in complex with a splicing modulator
Structure deposition date
2017-10-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
51
Peptide accession
O75533
Residue number A
933
Residue number B
965
Peptide name
Splicing factor 3B subunit 1
Ligandability
Cysteine 933 of Splicing factor 3B subunit 1
Cysteine 965 of Splicing factor 3B subunit 1
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