Low-density lipoprotein receptor-related protein 6
Intramolecular
Cysteine 599 and cysteine 612
Cysteine 900 and cysteine 914
Cysteine 293 and cysteine 308
Cysteine 1214 and cysteine 1228
Cysteine 916 and cysteine 929
Cysteine 310 and cysteine 323
Cysteine 614 and cysteine 627
Cysteine 1230 and cysteine 1243
Cysteine 1207 and cysteine 1218
Cysteine 592 and cysteine 603
More...Cysteine 893 and cysteine 904
Cysteine 599 and cysteine 603
Cysteine 286 and cysteine 297
Cysteine 293 and cysteine 297
Cysteine 900 and cysteine 904
Cysteine 1214 and cysteine 1218
Cysteine 286 and cysteine 293
Cysteine 1207 and cysteine 1214
Cysteine 893 and cysteine 900
Cysteine 592 and cysteine 599
Cysteine 904 and cysteine 914
Cysteine 297 and cysteine 308
Cysteine 599 and cysteine 627
Cysteine 1218 and cysteine 1228
Cysteine 612 and cysteine 627
Cysteine 1214 and cysteine 1243
Cysteine 1228 and cysteine 1243
Cysteine 592 and cysteine 612
Cysteine 603 and cysteine 612
Cysteine 893 and cysteine 914
Cysteine 900 and cysteine 929
Cysteine 308 and cysteine 323
Cysteine 286 and cysteine 308
Cysteine 914 and cysteine 929
Cysteine 293 and cysteine 323
Cysteine 1207 and cysteine 1228
Cysteine 1228 and cysteine 1230
Cysteine 612 and cysteine 614
Cysteine 900 and cysteine 916
Cysteine 1214 and cysteine 1230
3s94 B 599 B 612
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 599 and 612.
Details
Redox score ?
87
PDB code
3s94
Structure name
crystal structure of lrp6-e1e2
Structure deposition date
2011-05-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
599
Residue number B
612
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 599 of Low-density lipoprotein receptor-related protein 6
Cysteine 612 of Low-density lipoprotein receptor-related protein 6
5fww A 900 A 914
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 900 and 914.
Details
Redox score ?
87
PDB code
5fww
Structure name
wnt modulator kremen in complex with dkk1 (crd2) and lrp6 (pe3pe4)
Structure deposition date
2016-02-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
900
Residue number B
914
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 900 of Low-density lipoprotein receptor-related protein 6
Cysteine 914 of Low-density lipoprotein receptor-related protein 6
7nam A 293 A 308
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 293 and 308.
Details
Redox score ?
86
PDB code
7nam
Structure name
lrp6_e1 in complex with lr-eet-3
Structure deposition date
2021-06-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
293
Residue number B
308
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 293 of Low-density lipoprotein receptor-related protein 6
Cysteine 308 of Low-density lipoprotein receptor-related protein 6
3s8v A 1214 A 1228
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 1214 and 1228.
Details
Redox score ?
86
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
1214
Residue number B
1228
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 1214 of Low-density lipoprotein receptor-related protein 6
Cysteine 1228 of Low-density lipoprotein receptor-related protein 6
3s8v B 916 B 929
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 916 and 929.
Details
Redox score ?
85
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
916
Residue number B
929
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 916 of Low-density lipoprotein receptor-related protein 6
Cysteine 929 of Low-density lipoprotein receptor-related protein 6
3s94 A 310 A 323
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 310 and 323.
Details
Redox score ?
84
PDB code
3s94
Structure name
crystal structure of lrp6-e1e2
Structure deposition date
2011-05-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
310
Residue number B
323
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 310 of Low-density lipoprotein receptor-related protein 6
Cysteine 323 of Low-density lipoprotein receptor-related protein 6
3s94 B 614 B 627
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 614 and 627.
Details
Redox score ?
84
PDB code
3s94
Structure name
crystal structure of lrp6-e1e2
Structure deposition date
2011-05-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
614
Residue number B
627
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 614 of Low-density lipoprotein receptor-related protein 6
Cysteine 627 of Low-density lipoprotein receptor-related protein 6
4a0p A 1230 A 1243
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 1230 and 1243.
Details
Redox score ?
84
PDB code
4a0p
Structure name
crystal structure of lrp6p3e3p4e4
Structure deposition date
2011-09-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
1230
Residue number B
1243
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 1230 of Low-density lipoprotein receptor-related protein 6
Cysteine 1243 of Low-density lipoprotein receptor-related protein 6
3s8v B 1207 B 1218
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 1207 and 1218.
Details
Redox score ?
83
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
1207
Residue number B
1218
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 1207 of Low-density lipoprotein receptor-related protein 6
Cysteine 1218 of Low-density lipoprotein receptor-related protein 6
6l6r B 592 B 603
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 592 and 603.
Details
Redox score ?
82
PDB code
6l6r
Structure name
crystal structure of lrp6 e1e2-sost complex
Structure deposition date
2019-10-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
592
Residue number B
603
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 592 of Low-density lipoprotein receptor-related protein 6
Cysteine 603 of Low-density lipoprotein receptor-related protein 6
3s2k A 893 A 904
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 893 and 904.
Details
Redox score ?
81
PDB code
3s2k
Structure name
structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6
Structure deposition date
2011-05-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
893
Residue number B
904
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 893 of Low-density lipoprotein receptor-related protein 6
Cysteine 904 of Low-density lipoprotein receptor-related protein 6
4dg6 A 580 A 584
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 599 and 603 (580 and 584 respectively in this structure).
Details
Redox score ?
79
PDB code
4dg6
Structure name
crystal structure of domains 1 and 2 of lrp6
Structure deposition date
2012-01-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
7
% buried
61
Peptide accession
O75581
Residue number A
599
Residue number B
603
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 599 of Low-density lipoprotein receptor-related protein 6
Cysteine 603 of Low-density lipoprotein receptor-related protein 6
4dg6 A 267 A 278
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 286 and 297 (267 and 278 respectively in this structure).
Details
Redox score ?
78
PDB code
4dg6
Structure name
crystal structure of domains 1 and 2 of lrp6
Structure deposition date
2012-01-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
67
Minimum pKa ?
9
% buried
44
Peptide accession
O75581
Residue number A
286
Residue number B
297
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 286 of Low-density lipoprotein receptor-related protein 6
Cysteine 297 of Low-density lipoprotein receptor-related protein 6
7nam A 293 A 297
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 293 and 297.
Details
Redox score ?
74
PDB code
7nam
Structure name
lrp6_e1 in complex with lr-eet-3
Structure deposition date
2021-06-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
293
Residue number B
297
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 293 of Low-density lipoprotein receptor-related protein 6
Cysteine 297 of Low-density lipoprotein receptor-related protein 6
3s8v B 900 B 904
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 900 and 904.
Details
Redox score ?
72
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
900
Residue number B
904
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 900 of Low-density lipoprotein receptor-related protein 6
Cysteine 904 of Low-density lipoprotein receptor-related protein 6
6h15 B 1214 B 1218
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 1214 and 1218.
Details
Redox score ?
70
PDB code
6h15
Structure name
structure of lrp6 p3e3p4e4 in complex with vhh l-p2-b10
Structure deposition date
2018-07-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
1214
Residue number B
1218
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 1214 of Low-density lipoprotein receptor-related protein 6
Cysteine 1218 of Low-density lipoprotein receptor-related protein 6
3sov A 286 A 293
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 286 and 293.
Details
Redox score ?
66
PDB code
3sov
Structure name
the structure of a beta propeller domain in complex with peptide s
Structure deposition date
2011-06-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
286
Residue number B
293
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 286 of Low-density lipoprotein receptor-related protein 6
Cysteine 293 of Low-density lipoprotein receptor-related protein 6
4a0p A 1207 A 1214
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 1207 and 1214.
Details
Redox score ?
65
PDB code
4a0p
Structure name
crystal structure of lrp6p3e3p4e4
Structure deposition date
2011-09-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
1207
Residue number B
1214
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 1207 of Low-density lipoprotein receptor-related protein 6
Cysteine 1214 of Low-density lipoprotein receptor-related protein 6
6h15 B 893 B 900
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 893 and 900.
Details
Redox score ?
64
PDB code
6h15
Structure name
structure of lrp6 p3e3p4e4 in complex with vhh l-p2-b10
Structure deposition date
2018-07-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
893
Residue number B
900
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 893 of Low-density lipoprotein receptor-related protein 6
Cysteine 900 of Low-density lipoprotein receptor-related protein 6
3s94 A 592 A 599
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 592 and 599.
Details
Redox score ?
64
PDB code
3s94
Structure name
crystal structure of lrp6-e1e2
Structure deposition date
2011-05-31
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
592
Residue number B
599
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 592 of Low-density lipoprotein receptor-related protein 6
Cysteine 599 of Low-density lipoprotein receptor-related protein 6
3s8v A 904 A 914
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 904 and 914.
Details
Redox score ?
60
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
904
Residue number B
914
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 904 of Low-density lipoprotein receptor-related protein 6
Cysteine 914 of Low-density lipoprotein receptor-related protein 6
3sob B 297 B 308
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 297 and 308. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
3sob
Structure name
the structure of the first ywtd beta propeller domain of lrp6 in complex with a fab
Structure deposition date
2011-06-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
297
Residue number B
308
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 297 of Low-density lipoprotein receptor-related protein 6
Cysteine 308 of Low-density lipoprotein receptor-related protein 6
4dg6 A 580 A 608
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 599 and 627 (580 and 608 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
4dg6
Structure name
crystal structure of domains 1 and 2 of lrp6
Structure deposition date
2012-01-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
7
% buried
40
Peptide accession
O75581
Residue number A
599
Residue number B
627
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 599 of Low-density lipoprotein receptor-related protein 6
Cysteine 627 of Low-density lipoprotein receptor-related protein 6
3s2k B 1218 B 1228
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 1218 and 1228. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
3s2k
Structure name
structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6
Structure deposition date
2011-05-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
1218
Residue number B
1228
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 1218 of Low-density lipoprotein receptor-related protein 6
Cysteine 1228 of Low-density lipoprotein receptor-related protein 6
6l6r A 612 A 627
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 612 and 627. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
6l6r
Structure name
crystal structure of lrp6 e1e2-sost complex
Structure deposition date
2019-10-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
612
Residue number B
627
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 612 of Low-density lipoprotein receptor-related protein 6
Cysteine 627 of Low-density lipoprotein receptor-related protein 6
3s2k B 1214 B 1243
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 1214 and 1243. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
3s2k
Structure name
structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6
Structure deposition date
2011-05-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
1214
Residue number B
1243
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 1214 of Low-density lipoprotein receptor-related protein 6
Cysteine 1243 of Low-density lipoprotein receptor-related protein 6
3s2k B 1228 B 1243
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 1228 and 1243. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
3s2k
Structure name
structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6
Structure deposition date
2011-05-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
1228
Residue number B
1243
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 1228 of Low-density lipoprotein receptor-related protein 6
Cysteine 1243 of Low-density lipoprotein receptor-related protein 6
4dg6 A 573 A 593
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 592 and 612 (573 and 593 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
4dg6
Structure name
crystal structure of domains 1 and 2 of lrp6
Structure deposition date
2012-01-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
50
Peptide accession
O75581
Residue number A
592
Residue number B
612
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 592 of Low-density lipoprotein receptor-related protein 6
Cysteine 612 of Low-density lipoprotein receptor-related protein 6
4dg6 A 584 A 593
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 603 and 612 (584 and 593 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
4dg6
Structure name
crystal structure of domains 1 and 2 of lrp6
Structure deposition date
2012-01-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
54
Peptide accession
O75581
Residue number A
603
Residue number B
612
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 603 of Low-density lipoprotein receptor-related protein 6
Cysteine 612 of Low-density lipoprotein receptor-related protein 6
3s8v A 893 A 914
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 893 and 914. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
893
Residue number B
914
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 893 of Low-density lipoprotein receptor-related protein 6
Cysteine 914 of Low-density lipoprotein receptor-related protein 6
3s2k B 900 B 929
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 900 and 929. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
3s2k
Structure name
structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6
Structure deposition date
2011-05-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
900
Residue number B
929
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 900 of Low-density lipoprotein receptor-related protein 6
Cysteine 929 of Low-density lipoprotein receptor-related protein 6
4dg6 A 289 A 304
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 308 and 323 (289 and 304 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
4dg6
Structure name
crystal structure of domains 1 and 2 of lrp6
Structure deposition date
2012-01-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
22
Peptide accession
O75581
Residue number A
308
Residue number B
323
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 308 of Low-density lipoprotein receptor-related protein 6
Cysteine 323 of Low-density lipoprotein receptor-related protein 6
3s94 A 286 A 308
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 286 and 308. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
3s94
Structure name
crystal structure of lrp6-e1e2
Structure deposition date
2011-05-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
286
Residue number B
308
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 286 of Low-density lipoprotein receptor-related protein 6
Cysteine 308 of Low-density lipoprotein receptor-related protein 6
3s8v A 914 A 929
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 914 and 929. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
914
Residue number B
929
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 914 of Low-density lipoprotein receptor-related protein 6
Cysteine 929 of Low-density lipoprotein receptor-related protein 6
3s94 A 293 A 323
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 293 and 323. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
3s94
Structure name
crystal structure of lrp6-e1e2
Structure deposition date
2011-05-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
293
Residue number B
323
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 293 of Low-density lipoprotein receptor-related protein 6
Cysteine 323 of Low-density lipoprotein receptor-related protein 6
6h15 B 1207 B 1228
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 1207 and 1228. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6h15
Structure name
structure of lrp6 p3e3p4e4 in complex with vhh l-p2-b10
Structure deposition date
2018-07-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
1207
Residue number B
1228
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 1207 of Low-density lipoprotein receptor-related protein 6
Cysteine 1228 of Low-density lipoprotein receptor-related protein 6
3s8v B 1228 B 1230
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 1228 and 1230. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
3s8v
Structure name
crystal structure of lrp6-dkk1 complex
Structure deposition date
2011-05-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
1228
Residue number B
1230
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 1228 of Low-density lipoprotein receptor-related protein 6
Cysteine 1230 of Low-density lipoprotein receptor-related protein 6
3s94 B 612 B 614
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 612 and 614. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3s94
Structure name
crystal structure of lrp6-e1e2
Structure deposition date
2011-05-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
612
Residue number B
614
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 612 of Low-density lipoprotein receptor-related protein 6
Cysteine 614 of Low-density lipoprotein receptor-related protein 6
6h15 B 900 B 916
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 900 and 916. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
6h15
Structure name
structure of lrp6 p3e3p4e4 in complex with vhh l-p2-b10
Structure deposition date
2018-07-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
900
Residue number B
916
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 900 of Low-density lipoprotein receptor-related protein 6
Cysteine 916 of Low-density lipoprotein receptor-related protein 6
3s8z A 1214 A 1230
A redox-regulated disulphide may form within Low-density lipoprotein receptor-related protein 6 between cysteines 1214 and 1230. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3s8z
Structure name
crystal structure of lrp6-e3e4
Structure deposition date
2011-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75581
Residue number A
1214
Residue number B
1230
Peptide name
Low-density lipoprotein receptor-related protein 6
Ligandability
Cysteine 1214 of Low-density lipoprotein receptor-related protein 6
Cysteine 1230 of Low-density lipoprotein receptor-related protein 6
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