Ribosomal protein S6 kinase alpha-5

Intramolecular

A redox-regulated disulphide may form within Ribosomal protein S6 kinase alpha-5 between cysteines 631 and 714 (630 and 713 respectively in this structure).

Details

Redox score ?

PDB code

7up5

Structure name

crystal structure of c-terminal domain of msk1 in complex with covalently bound pyrrolopyrimidine compound 23 (co-crystal)

Structure deposition date

2022-04-14

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

O75582

Residue number A

631

Residue number B

714

Peptide name

Ribosomal protein S6 kinase alpha-5

Ligandability

Cysteine 631 of Ribosomal protein S6 kinase alpha-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 714 of Ribosomal protein S6 kinase alpha-5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribosomal protein S6 kinase alpha-5 between cysteines 440 and 443. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?