ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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PR domain zinc finger protein 1

Intramolecular
Cysteine 176 and cysteine 201
Cysteine 58 and cysteine 176
A redox-regulated disulphide may form within PR domain zinc finger protein 1 between cysteines 176 and 201 (139 and 164 respectively in this structure).

Details

Redox score ?
70
PDB code
3dal
Structure name
methyltransferase domain of human pr domain-containing protein 1
Structure deposition date
2008-05-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
95
Peptide accession
O75626
Residue number A
176
Residue number B
201
Peptide name
PR domain zinc finger protein 1

Ligandability

Cysteine 176 of PR domain zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of PR domain zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within PR domain zinc finger protein 1 between cysteines 58 and 176 (21 and 139 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
3dal
Structure name
methyltransferase domain of human pr domain-containing protein 1
Structure deposition date
2008-05-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
88
Peptide accession
O75626
Residue number A
58
Residue number B
176
Peptide name
PR domain zinc finger protein 1

Ligandability

Cysteine 58 of PR domain zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 176 of PR domain zinc finger protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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