ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ficolin-3

Intramolecular
Cysteine 86 and cysteine 110
Cysteine 245 and cysteine 258
Cysteine 93 and cysteine 121
A redox-regulated disulphide may form within Ficolin-3 between cysteines 86 and 110 (63 and 87 respectively in this structure).

Details

Redox score ?
88
PDB code
2j60
Structure name
h-ficolin complexed to d-fucose
Structure deposition date
2006-09-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75636
Residue number A
86
Residue number B
110
Peptide name
Ficolin-3

Ligandability

Cysteine 86 of Ficolin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Ficolin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ficolin-3 between cysteines 245 and 258 (222 and 235 respectively in this structure).

Details

Redox score ?
84
PDB code
2j5z
Structure name
h-ficolin complexed to galactose
Structure deposition date
2006-09-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75636
Residue number A
245
Residue number B
258
Peptide name
Ficolin-3

Ligandability

Cysteine 245 of Ficolin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 258 of Ficolin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ficolin-3 between cysteines 93 and 121 (15 and 43 respectively in this structure).

Details

Redox score ?
83
PDB code
2j64
Structure name
h-ficolin
Structure deposition date
2006-09-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
O75636
Residue number A
93
Residue number B
121
Peptide name
Ficolin-3

Ligandability

Cysteine 93 of Ficolin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Ficolin-3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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